Does anyone on Azilect/ Rasagiline experienced slow down of progression of PD?

[TL500]

Does anyone benefit from this?Thanks

[Hidden]

drugs.com/comments/rasagili...

[TL500 in reply to Hidden]

Thanks

[LeharLover62]

I’m not sure how you would know for sure if it slowed your progression. Hubby’s former Stanford MDS thought there wasn’t enough evidence to support spending the money on it. But prior to Stanford, he took it for about 10 years from his first diagnosis on. I will say that it definitely causes him to move better. Though he’s been mostly off it now for a few years.

[TL500 in reply to LeharLover62]

Thanks. Why is he off it now?

[LeharLover62]

He hallucinates if he takes it now. (He’s hypersensitive to all Parkinson’s meds at this point in his illness).

[TL500 in reply to LeharLover62]

Is there anything that help him his current symptoms?

[LeharLover62 in reply to TL500]

Well, not much. He is helped by some dementia drugs like revastigmine and mementine. He can only tolerate micro doses of any dopamine medication (Neupro seems to work best, but we’ve tried everything from azilect to Macuna in the last year)

[TL500 in reply to LeharLover62]

Thanks

[bandmember]

who knows? I’ve been taking it for more than four years with 3x100/25 Madopar tablets per day. I don’t have off times - even when I forget to take a dose and haven’t felt the need to increase it. I do have off days - usually after a bad night’s sleep or a day when I’ve tried to do too much. Otherwise, it’s not too bad. Is it Azilect - or exercise - or just I have a slower developing version of PD? No idea - but I’ll keep on taking it. Fortunately, I live in Australia and prescribed meds are heavily subsidised.

[TL500 in reply to bandmember]

Thanks bandmaster I love in Australia too, my Azilect costs $40+

[4000Nights]

I have been on Azilect and the generic Rasagiline since I was diagnosed eight years ago, and I believe my progression has been far less than I feared it would be. I still walk without a cane or an aid of any sort… still drive… still work. Relatives and friends I haven’t seen in a few years partly because of the pandemic say they see no change. I strongly recommend it for those recently diagnosed and/or in early stages.

And really… which way do you want to be wrong? Take it and have it not work, or not take it when it would have worked.

[TL500 in reply to 4000Nights]

Thanks. Your comment is true, only that I fear of all the side effects. It seems I get very bad constipation, and not sure if stiffer when off.Did you take any other PD meds beside Azilect/Rasagiline?

Or have to take it now?

[TL500 in reply to 4000Nights]

Sounds good. I think i should have taken it in the beginning. I didn't want to take any PD meds and my symptoms got worse over time so my neurologist said Azilect would not do anything for me as I'm not mild anymore.

[4000Nights]

i have mild constipation which I never associated with Rasagiline directly. But I treat it with diet and OTC drugs when I need to. I'd rather have a little constipation than phase 3 PD.

I take generic Sinemet to lessen the PD symptoms I have. I find they work well together

[TL500 in reply to 4000Nights]

I don't know whether to taking Azilect, PS128 and Restore Gold causing severe constipation or my PD is progressing. I tried more fibers and some fruits and banana and water, but still difficult so I graduall

[park_bear in reply to TL500]

See here for constipation:

healthunlocked.com/cure-par...

[TL500 in reply to park_bear]

Thanks

[TL500 in reply to 4000Nights]

Gradually went of it like half tablet per day for one week then off. But then because I saw comments that it seemed help slow the progression so I started again 1mg/ day yesterday.By the evening I had headache just yesterday, and been coughing (for a week or so) and today headache, heat cough, runny nose, funny tummy (took vitamin C and magnesium this morning) flu like symptoms so don't know it's side effects or COVID. I stopped taking it today as neuro told be before if I want to stop then just stopped

Just gone tested covid.

Has anyone have side effects like flu symptoms?

[EmptyNester3]

I would probably say yes. My MDS thinks I am doing very well for almost 10 years diagnosed...I was 48. I do take C/L 25/100 as well...4 pills but sometimes 3 or 4.5. I don't work so push thru a few hours of "off" time by choice as I don't want to take any more than absolutely needed...also just began B1 therapy in October...while medicated you wouldn't know I had it. It just recently started moving to my right side and anxiety has been increasing a lot.