Dihexa peptide shows potential for PD and... - Cure Parkinson's

Cure Parkinson's

26,511 members27,917 posts

Dihexa peptide shows potential for PD and ALZ and (I believe) is currently available

Little_apple profile image
12 Replies

hypothesis, demonstrating that Dihexa, given by abdominal injection or orally, completely restored lost motor function. Moreover, staining for tyrosine hydroxylase (TH), a marker for the dopamine neurons that were lost following chemical lesioning, returned to near normal after 34 days of treatment. Studies are still ongoing to determine whether this recovery of TH staining was due to the presence of new nerve cells and/or the expansion of the appendages of surviving neurons.

michaeljfox.org/grant/devel...

Note this is 2012 MJFF. Peptides can not be patented so…

ncbi.nlm.nih.gov/pmc/articl...

Written by
Little_apple profile image
Little_apple
To view profiles and participate in discussions please or .
Read more about...
12 Replies
reedboat2 profile image
reedboat2

L_a you are quite the researcher. Well done!

park_bear profile image
park_bear

A nootropics website is selling what they say is dihexa for $130 a gram. Found some at a chemical supply house, $700 for 10 milligrams. Also found a questionable clinic that allegedly offers it as therapy.

park_bear profile image
park_bear in reply topark_bear

Available from China at $70-$80 per gram. alibaba.com/

For dosage I found a mouse study of dihexa in Alzheimer's: researchgate.net/publicatio...

The equivalent human dose for the most effective mouse dosage, 2.88 mg/kg, would be .24 mg/kg, amounting to about 15 milligrams daily for a 60 kilogram human. 15 milligrams is just a tiny pinch of substance. One gram of dihexa would last a couple of months for anyone brave enough to try this.

park_bear profile image
park_bear

I also found this reference to successful unpublished work:

frontiersin.org/articles/10...

"Our laboratory has recently synthesized [dihexa] to overcome the motor dysfunctions that follow 6-OHDA-induced lesions of the substantia nigra pars compacta in the rat (unpublished results). This compound, called Dihexa, significantly improved both rope hang times and stride length over the course of a 48-day treatment period."

Little_apple profile image
Little_apple

This doctor has a lot of info on peptides abs might be able to direct us where to get this. Just found this site

apeironzoh.com/dt_team/dani...

robinson621 profile image
robinson621

Has anyone tried this stuff? i would like to know about side effects, also its available here.

swisschems.is/ref/337/

Fumaniron profile image
Fumaniron

Very interesting. I'd love to hear someone's philosophy on their dosage and how long they plan on taking Dihexa

realk profile image
realk

Wtf ....is this a joke or what? Are there any news on this study?Or there is no interest to follow up because it's so cheap and effective?I

Godourtruehealer profile image
Godourtruehealer

Any update from anyone who tried this?

Bear1927 profile image
Bear1927 in reply toGodourtruehealer

I will try and post some feedback

All of my previous and current attempts clearly helped me to stop PD progression and reduce the amount of medication, perhaps even reverse it a bit, so I have a high hopes!

Bear1927 profile image
Bear1927

biolabshop.co.uk/nootropics...

I'll give it a go!

Not what you're looking for?

You may also like...

Potential Diagnostic Tool, Treatment for PD

"Investigators have pinpointed a molecular defect that seems almost universal among patients with...
rebtar profile image

One-time treatment generates new neurons, eliminates Parkinson's disease in mice

A groundbreaking study lights up a new way of approaching PD treatment . " Researchers around the...
Abdiqani profile image

New Study Shows Another Method of Action of Melatonin to Fight PD and AD, Modulation of Endoplasmic Reticulum Stress

In this January 2023 study melatonin is suggested to be useful in PD and AD via modulation of...
chartist profile image

Fibromyalgia In PD And Some Potential Relief

Fibromyalgia (FM) is slightly more common in people with PD and FM can cause all over body pain...
chartist profile image

Mitochondrial uncoupling ; can this help PD, appears maybe

“Apoptosis induced by MPP+ was ameliorated by NTZ in a dose-dependent manner. In vivo results...