One-time treatment generates new neurons, eliminates Parkinson's disease in mice

[Abdiqani]

A groundbreaking study lights up a new way of approaching PD treatment .

" Researchers around the world have tried many ways to generate neurons in the lab, using stem cells and other means, so we can study them better, as well as to use them to replace lost neurons in neurodegenerative diseases," said Fu, who is a Distinguished Professor in the Department of Cellular and Molecular Medicine at UC San Diego School of Medicine. "The fact that we could produce so many neurons in such a relatively easy way came as a big surprise." There are several different ways to mimic Parkinson's disease in mice. In this case, the researchers applied a dopamine look-a-like molecule to poison neurons that produce dopamine. As a result, the mice lose dopamine-producing neurons and develop symptoms similar to Parkinson's disease, such as movement deficiencies.

The treatment works like this: The researchers developed a noninfectious virus that carries an antisense oligonucleotide sequence—an artificial piece of DNA designed to specifically bind the RNA coding for PTB, thus degrading it, preventing it from being translated into a functional protein and stimulating neuron development." Study Notes .

This could lead having more targeted way of PD treatment and to figuring out its basis as still remains unabated .

More Info :

medicalxpress.com/news/2020...

[Hidden]

Could you check recent posts before posting?

[Abdiqani in reply to Hidden]

please , clarify your Question .

[Hidden in reply to Abdiqani]

I'm asking that you might check to see if what you are posting hasn't already been posted. This article has already been posted today.

[Abdiqani in reply to Hidden]

It doesn't matter if you have already seen a similar article or may be talked about same topic but different update researches. Thanks for your attention !

[Hidden in reply to Abdiqani]

You posted the exact same article that was posted earlier today.

healthunlocked.com/parkinso....

[Abdiqani in reply to Hidden]

Okay , I got it .

[MarionP in reply to Abdiqani]

Abd, Don't you quit, yours was the only mention I saw, here.

[pdpatient in reply to Abdiqani]

Hi Abdiqani. Thanks for your post. Very helpful. Please continue to post and share your thoughts and research. Don't worry about the duplicate posts. It is the moderators responsibility to weed out a duplicate post through software or active moderation. I know that it can be done. However, some people like you for instance are better at posting than others 😉 So, post on ahead!!

[ElliotGreen in reply to Abdiqani]

Abdiqani,

Your post was better, because you actually gave an indication of the content in your title. I didn't look at the other post.

[Giovi1960 in reply to Abdiqani]

Thanks for posting, I hadn't seen a previous posting of this article. And I don't care if it's duplicated. If I had seen it before, it's up to me if I read it again or not. Thanks again, Abdiqani.

[Jennyjenny2 in reply to Hidden]

Really??

You have 2 choices...

1. Read it

2. Don’t read it

Simple!

[Seamus6 in reply to Abdiqani]

Personally, I don't find duplication of posts irritating (though I know some do) - I'd rather have something double posted than miss something important.

I hope people aren't discouraged from posting - now that would be a shame.

[MarionP in reply to Seamus6]

Yes, when someone just up and tells you to shut up it always should be considered with a grain of salt, for the exact reason you stated. They'll get over it somehow...maybe. Or not. We have a Samoyed like that, can never let the cat meow, if the cat says anything it's like somebody farted in church, big ruffle from the puppy, dog comes running over to bitc*slap the kitty. Needs some reindeer to herd is all we can figure.

[gwendolinej in reply to MarionP]

Well said Marion 👍

[NellieH in reply to Seamus6]

Agreed.

[Enidah in reply to Abdiqani]

Thank you for posting this! Good news is always welcome!

[Rhyothemis in reply to Hidden]

The previous post had no description so it is hard to know what it was about. It would be nice if people provided some description or perhaps a copy/paste excerpt; this works especially well if people are conscious of the key words they are providing like names of drugs, genes, researchers - the more specific, the better. Providing the exact title of the original article is also very useful. This is needed if people are to use the search feature effectively. I have tried searching before posting to reduce duplication; that doesn't work if there are no/few key words to search on.

Like I said, it would be nice if people did that - but I understand people are busy. I am not going to fault anyone either way.

[MBAnderson in reply to Hidden]

ChrisWF,

In summary, so what? It's a common occurrence. It's happened hundreds of times.

I did not see the earlier posts and am appreciative of seeing the 2nd posting because it reminds me I wish I were a mouse.

Seems to me it's easy enough to just not read a post a 2nd time.

Then you got the problem of people like me who like to tell the same story over and over.

[Hidden in reply to MBAnderson]

Well, the forum rules (and I'm aware that you think the forum basically shouldn't have any rules so acknowledge that you likely don't care) do actually request:

"When posting recent news please review recent posts to ensure you are not duplicating an existing post."

So it's not an outrageous request.

[MBAnderson in reply to Hidden]

Actually, every single subject on this forum has been raised more than once and some discussions are more thorough than others is why it's a bad rule.

Yes, I wish the HU administrators were more open to users input.

Why don't you just not read duplicates?

[Hidden in reply to MBAnderson]

Why do you suppose the forum rules ask that people avoid posting duplicates?

[MBAnderson in reply to Hidden]

Because they have not thought through the fact that a valuable post and discussion may well be unknown to everybody who comes on the forum afterwards.

Questions about dosing Mucuna Pruriens arise almost every week and if they forbid duplicate content, 90% of the people would be deprived of that information.

Just because there's a rule about something, doesn't make it is constructive.

As we all know, the world is filled with misguided rules.

My concern is that your complaining about it discourages people from posting.

[Hidden in reply to MBAnderson]

I think the claim that you suddenly fear that people wont feel comfortable posting becuase of things posted by others is complete bollocks. It was only a month or so ago that you were in favour of the place being a hotspot for conspiracy theories that had nothing to do with PD. Your rationale? You found it entertaining.

You didn't seem especially concerned about that nonsense driving people away from the place. Your remedy? Just dont read it. So forgive me if i find your supposed interest in the safety of this space to be....completely implausible.

And what about your passion for straw man arguments? Perhaps that practice steers people clear of the forum also.

I never said there should only be one mucuna thread or on B1 thread or whatever. Frankly without the daily barrage of mucuna and b1 threads this place would probably grind to a halt.

Have you seen me posting on mucuna or b1 threads, suggesting that the OP find an existing thread? I doubt it.

So why suggest that was my argument?

The passage from the rules refers specifically to 'recent news'. Personally, I have no trouble understanding the merit of it, but I gather there are many who don't share that view!

[ElliotGreen in reply to Hidden]

I think that the amount of verbiage spilled over complaining about another post is much more annoying than the second post. Especially since the first one didn't have a good title. Crikey!

[WinnieThePoo in reply to MBAnderson]

Trouble is Marc, you've missed all the good points on the other thread. Wouldn't you rather read all the comments about IDENTICAL articles posted within hours of each other in just one place. I only looked at this thread because it became controversial. First time I skipped it as an obvious lazy duplicate

[Hidden in reply to WinnieThePoo]

This is how i feel about it, but apparently it's an unpopular view.

[WinnieThePoo in reply to Hidden]

I wouldn't lose sleep over it

[MBAnderson in reply to Hidden]

Chris, Poo pointed out to me that you for probably feel set upon. Sorry for that.

[MBAnderson in reply to WinnieThePoo]

Richard,

Yes I would, but since many of us don't see every thread at the time they're posted, so I feel it's a very good thing that many of these threads are re-posted.

Chris responded as though I am some kind of anarchist, when, I simply prefer the option of choosing not to read something rather then chastising people for what they post.

marc

[WinnieThePoo in reply to MBAnderson]

Yes I noted the tone. Maybe he was feeling set upon. It looks a hostile environment for him. I have far more important things to worry about, but I understand where Chris is coming from on the specific subject of trying to carry out a quick scan to see whether there is an existing post you can comment on, and keep one coherent discussion before starting a duplicated thread.

Some people appear to use the forum just to broadcast news and not participate in discussion, and may be less aware of the desirability of keeping a discussion coherent. It takes all sorts i guess.

[ParlePark in reply to Hidden]

Chris, I did the first posting and my title was not as informative as Abdiqani’s. It’s really no biggie.

[Hidden in reply to ParlePark]

I don't think it's a biggie. I'm not wild about duplicate posts on the same day because it's fairly trivial to skim through that day's posts to see if its already been posted. Clearly, others hold different views which is cool. MBA wants to argue about it now, which i dont reallt understand but hey, whatever floats your boat.

[pdpatient in reply to ParlePark]

ParlePark. Great comraderie!

[MarionP in reply to Hidden]

Hey Chris, before posting to tell someone to not duplicate a post, can you please check for recent posts telling people not to post?

[Hidden in reply to MarionP]

Well if there's one person thatl never be accused of reposting, it'd be you 😂

[Despe in reply to Hidden]

Try B1 questions! You should have thanked Abdiqani for taking time and posting such important findings, not scolding him.

[sharoncrayn in reply to Abdiqani]

Could you check recent posts before posting?

[aspergerian13]

Wow!

[Kevin51]

Amazing results 🙂 " Using a chemically induced model of Parkinson’s disease in mouse, we show conversion of midbrain astrocytes to dopaminergic neurons, which provide axons to reconstruct the nigrostriatal circuit." It's the wiring that matters, of course. nature.com/articles/s41586-...

[Rhyothemis in reply to Kevin51]

Yes, that fact that the new neurons 'worked' is quite encouraging.

[Xenos in reply to Rhyothemis]

... to says the least !

[Gioc]

This is the kind of discovery that makes the history of research and medicine. Congratulations ... it's fantastic. Thank you.

[Parkie-]

Thank you for posting, Abdiqani.

[Biff69]

Thanks for posting

[Lana666]

There are subjects which are posted multiple times because of their importance or other reasons. They are commented by different people at different time and each thread develops in it’s own way with different information and points of view - therefore making all of them valuable. This forum is to help us to get and share information and experience and encouragement. I don’t see anything wrong if someone needs to ask same question or excited to share the same news - whatever it takes to get help.

[sharoncrayn in reply to Lana666]

"There are subjects which are posted multiple times because of their importance or other reasons."

This study isn't one. In the deep weeds micro biologists have studies PTB and its relationship to RNA since the 1990s. Deleting a single gene in mice isn't quite as simple as doing the same in humans.

[Gioc in reply to sharoncrayn]

True! The complexity of silencing or deleting someone or something in humans is also well represented in this thread.

[MarionP in reply to Gioc]

Didn't someone already post that? Oh, well maybe not in so many words. Was it just different enough to not quite qualify as a re-post? Maybe we should check your post against recent re-posts. Can you just check that yourself next time, that way we won't have to check all the posts to see that they weren't re-posted, that would just be duplicating others' reposted posts.

I wonder what Graham Chapman would think about this conversation.

[sharoncrayn in reply to Gioc]

Yes Gio, we all have dreams. Dream big I say. Fantasize your neuroscience deep weed dreams into reality. See them come into reality by 2050. Let me get my scalpel and join you in the glorious march towards brain surgery nirvana. How wonderful it will be. I can't wait. So what if we lose a few brave souls along the way. Our comrades here will honor us for our glorious adventure. We must find humans who have brains similar to mice, but once we do the sky is the limit.

""It's my dream to see this through to clinical trials, to test this approach as a treatment for Parkinson's disease, but also many other diseases where neurons are lost, such as Alzheimer's and Huntington's diseases and stroke," Fu said. "And dreaming even bigger—what if we could target PTB to correct defects in other parts of the brain, to treat things like inherited brain defects?"

"The model the team used doesn't perfectly recapitulate all essential features of Parkinson's disease. But the study provides a proof of concept, Fu said."

Well said comrade Fu; well said.

[Gioc in reply to sharoncrayn]

Dear Sharon,

Eventually we could at this point find out that John Pepper is right. The secret of youth lies in pushing the body to act with willpower and this forced use will repair it: exercise! Exercise! Exercise!

the Function will repair the Structure was an ancient Vedic concept also expressed by my physiotherapist.

I say this for completeness of fantasy expressed by this study and to make difficult life for the "hard and pure materialists" .

We always have a dream because this is how we operate towards the goal: a world where neurovegetative diseases no longer scare anyone.

[sharoncrayn in reply to Gioc]

I will meditate on your philosophy as I ride my stationary spin bike in the Chinese Dragon Boat Festival parade here in Hoboken, NY. Spin, spin, spin. Round and round I go, but with nowhere to go.

Long live the poet Qu Yuan and his disciple Gio!

[ParlePark in reply to sharoncrayn]

You mean Hoboken, NJ.

[sharoncrayn in reply to ParlePark]

literary license

[Gioc in reply to sharoncrayn]

Sharon,Poets do not roam places in the world, they create places with their ability to look at the dimension which is the true essence of space, but this is another thing. I always appreciate what you write. Long live to you too Sharon and thank you.😀

[sharoncrayn in reply to Gioc]

Gio,

"they create places with their ability to look at the dimension which is the true essence of space"

I should have quoted something from Ezra Pound, the ex pat who lived in Italy and worshiped Benito, (and in some ways ended up like Benito) but he never wrote about mice, or perhaps Michelangelo. No, not Michelangelo he came from outer "space" and landed in Italy of all places. Maybe Gatto. No. I should have quoted something from Dante Alighieri. il Sommo Poeta.

Did you know comrade Fu of microbiology fame on this forum and mice PTB fame is a style of ancient Chinese poetry? Go figure.

[Gioc in reply to sharoncrayn]

I understand you Sharon,

To stay in your field.

I didn't know Comrade FU, but I know Ernest Arenas at the Department of Biochemistry and Medical Biophysics at the Karolinska Institute, I've heard of him. (article quoted at the end of this:

medicalxpress.com/news/2017... ).

As you said, these things are very different when reported on humans and they are also dangerous, and the subject is not new either, but who's ever worked on it?

Maybe no one will ever do these trials on humans.

However, I find it interesting.

The neuron can be reproduced by the body itself (of mice) and cooperate with other neurons !

This is not a joke about intelligence, because having PD doesn't mean we are as stupid as some people here believe, not you.

[sharoncrayn in reply to Gioc]

KI does some very good research. Arenas does dopamine research.

[sharoncrayn in reply to Gioc]

Fu's approach is very different from what Arenas is attempting to do with midbrain dopaminergic neurogenisis and cell replacement therapy. In addition to his “Reprogramming astrocytes into disease resistant dopaminergic neurons“.

Real deep in the weeds molecular biology.

[Drummer67 in reply to Lana666]

Well said lana666. To me the important thing here is this seems like potentially a game changer. My concern is the hope to get this at warp speed in the lab and get it out to the people it can help which is us Parkies

[Fighttolivenow]

Thanks Abdiqani...most of your posts are pretty interesting

[PalmSprings]

There were at least 2 different articles by different reporters that read a little differently and I found them both fascinating! I don’t know about you but even if I had read the article a second or even a third time, I get something new out of it, so post away!

I hope the human trials come quickly and I would sign up.

[WinnieThePoo]

What does anyone think about the 3rd more recent posting of the same news item?

[bassofspades]

Yay for those lucky mice again!

I see hope and more hope but I never see it materialize into something that helps real people in the general public . Why do all of these promising therapies fall by thewayside?

Please no evil big pharma conspiracy theories again!

Thanks again for posting and reposting.