peptide for PD : Neuroprotective Effects of a Small Mitochondrially-Targeted Tetrapeptide Elamipretide in Neurodegeneration

[Little_apple]

pubmed.ncbi.nlm.nih.gov/351...

2011 - not human - MJFF

We found that the peptide can be reduced up to tetrapeptide that still has potent neuroprotective and cell-penetrating properties. The tetrapeptide dose-dependently promoted survival of cultured embryonic mouse dopaminergic neurons and spontaneously penetrated the neurons, but had any obvious effect on the cultured non-neuronal cells. In the proof-of-principle in vivo neuroprotective experiment, the tetrapeptide effectively counteracted the Parkinsonian symptoms caused by 6-hydroxydopamine: it significantly reduced the amphetamine-induced rotation of the animals. The effective dose of the peptide for in vivo experiments was found.  

michaeljfox.org/grant/novel...

[jeffmayer]

Translation would be nice