Intranasal delivery of mitochondria targeted neuroprotective compounds for traumatic brain injury

[Bolt_Upright]

Interesting Read: Intranasal delivery of mitochondria targeted neuroprotective compounds for traumatic brain injury: screening based on pharmacological and physiological properties 2024 translational-medicine.biom...

"Abstract

Targeting drugs to the mitochondrial level shows great promise for acute and chronic treatment of traumatic brain injury (TBI) in both military and civilian sectors. Perhaps the greatest obstacle to the successful delivery of drug therapies is the blood brain barrier (BBB). Intracerebroventricular and intraparenchymal routes may provide effective delivery of small and large molecule therapies for preclinical neuroprotection studies. However, clinically these delivery methods are invasive, and risk inadequate exposure to injured brain regions due to the rapid turnover of cerebral spinal fluid. The direct intranasal drug delivery approach to therapeutics holds great promise for the treatment of central nervous system (CNS) disorders, as this route is non-invasive, bypasses the BBB, enhances the bioavailability, facilitates drug dose reduction, and reduces adverse systemic effects. Using the intranasal method in animal models, researchers have successfully reduced stroke damage, reversed Alzheimer’s neurodegeneration, reduced anxiety, improved memory, and delivered neurotrophic factors and neural stem cells to the brain. Based on literature spanning the past several decades, this review aims to highlight the advantages of intranasal administration over conventional routes for TBI, and other CNS disorders. More specifically, we have identified and compiled a list of most relevant mitochondria-targeted neuroprotective compounds for intranasal administration based on their mechanisms of action and pharmacological properties. Further, this review also discusses key considerations when selecting and testing future mitochondria-targeted drugs given intranasally for TBI."

[SAGoodman]

Wow, maybe a very positive treatment for PD!

[gomelgo]

How is the oxytocin going?

[Bolt_Upright in reply to gomelgo]

I use one squirt per nostril twice a day. Is it helping? I don't know. I am better than I was 3 years ago, but I was never diagnosed with PD. And, I do a lot of things. rbd-pd-protocols.blogspot.c...

[pad99999]

You do not use drugs that increase dopamine ?

[Bolt_Upright in reply to pad99999]

I have not been diagnosed with PD. I was diagnosed with REM Sleep Behavior Disorder in April 2021. At that time I also had some symptoms of PD. Balance issues. Sore neck and really sore left shoulder and sore left leg. I also had random muscle jerks and sometimes a tremor in my left pinkie. That was rare.

My RBD is much better now. I have not seen my pinkie tremor in well over 6 months. My neck and shoulder are still sore, but less sore. My twitches and jerks are also way down.

I can't put this down to the Oxytocin as I do a lot of things (including retiring!): rbd-pd-protocols.blogspot.c...