Anti-acrolein scavengers such as hydralazine - Another drug that lowers BP - could be used to treat PD

[p-oui]

‘Key Factor’ In Development Of Parkinson’s Disease Identified:

1. Acrolein appears to destroy neurons

2. Hydralazine, a drug used to treat high blood, scavenges Acrolein

3. Salbutamol (also known as albuterol) could reduce the risk of Parkinson’s disease by half. It acts by a different mechanism than hydralazine – but reduces alpha-synuclein accumulation

4. Evaluating whether salbutamol and an acrolein-scavenging drug, such as hydrazine, could be used together to achieve an even greater benefit for PWP.

pressurescienceblog.com/500401/key-...

[andrehypnotic]

Wow o

[p-oui in reply to andrehypnotic]

Looks promising! purdue.edu/newsroom/release...

[JohnPepper]

This sounds crazy to me. Taking medication for Pd that has not been properly tested for side effects or being appropriate for Pd, other than by the company selling it. Or am I missing something?

[jeffreyn in reply to JohnPepper]

John, we're all missing something, and that something is "context".

The "link" to the supporting article didn't come through correctly.

Here is the corrected link:

scienceblog.com/500401/key-...

The article linked to discusses a recent research paper (i.e. it is not about PwPs experimenting with new drugs).

[p-oui in reply to jeffreyn]

Thanks Jeffreyn, I thought this drug looked v. promising but it is not even in trials. It sounds similar to the Israpidine study and designed to indirectly target ASN clumps. The israpidine trial is a well funded Phase 3 trial

[p-oui in reply to jeffreyn]

Check this link out also: purdue.edu/newsroom/release...