Sonic hedgehog can suppress L-dopa induced dyskinesia

parkinsonsnewstoday.com/202...

[Giovi1960]

Thanks for sharing, nedim. So, as I understand, it is safe to say that taking levodopa and an agonist together is the best recipe to avoid dyskinesia?

[Hidden in reply to Giovi1960]

I understood sonic hedgehog agonists not dopamine agonists....right?

[Giovi1960 in reply to Hidden]

Oops, I think you're right!

[jeffreyn]

See also the following recent SoPD blog post from Simon:

scienceofparkinsons.com/202...

[sharoncrayn in reply to jeffreyn]

and deep into the proverbial gene protein weeds we go. merrily, merrily. round and round we go finding association after association but no cure is in sight even with my big telescope. how can that be? way back in1995 sonic was talked about, and we still are trying to figure out what to do.

but if I don't publish, I perish. levodopa(sinemet, etc.) treats the motor features of the condition but only hides/masks the fact that the disease is still progressing.

"Sonic hedgehog is produced by dopamine neurons and released on to target cells, which can be stimulated by it. In Parkinson’s, this stimulation is missing – given the loss of the dopamine neurons that release sonic."

I guess that sums it up.

sharon

[JayPwP]

There used to be video game by that name.