Green Tea Polyphenols Attenuated Glutamate Excitotoxicity via Antioxidative and Antiapoptotic Pathways

[SilentEchoes]

Neurodegenerative diseases are a wide class of hereditary and sporadic conditions characterized by progressive nervous system dysfunction. These disorders include Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS) which are caused by a combination of genetic and environmental factors.

It has been shown that glutamate excitotoxicity induced oxidative stress is linked to neurodegenerative diseases.

Growing evidence suggests that the mitochondrial dysfunction mediated by glutamate excitotoxicity-induced oxidative stress was associated with both acute and chronic neurodegenerative disorders.

We found that green tea polyphenols protected against glutamate induced neurotoxicity in the cortical neurons.

Furthermore, our results demonstrated that green tea polyphenols restored the dysfunction of mitochondrial pro- or antiapoptotic proteins Bax, Bcl-2, and caspase-3 caused by glutamate. hindawi.com/journals/omcl/2...

Green tea polyphenols have been found to be more antioxidant active than vitamin C and vitamin E. Furthermore, green tea polyphenols were shown to protect against beta-amyloid toxicity in the primary cultured cortical neurons.

WHAT IS IN GREEN TEA LEAVES THAT IS GOOD FOR YOU?

Epigallocatechin gallate (EGCG)

Epicatechin gallate (ECG)

L-theanine

Caffeine

THE BEST WAY TO CONSUME GREEN TEA POLYPHENOLS

With the catechins, EGCG, and ECG being the stars of this health-promoting, anti-aging story, one might assume taking a green tea extract is the best idea; however, in an article, the researchers recommend drinking green tea daily. The concern is that supplements could contain high doses of catechins which can pose a problem for the energy-making battery packs inside cells (mitochondria), including potential to cause cell death.

SE 🍵

[Hidden]

Off to have green tea! Great post. Thank you

[SilentEchoes in reply to Hidden]

❤️❤️

[Hidden in reply to SilentEchoes]

Green tea, especially matcha, although very healthy in some ways, is very high in oxalates and is known to cause kidney stones That said, for most, the benefits exceed the risk imho

[Despe]

I actually combine teas: Green tea, Moringa tea, and black tea. I also use orange peels with a Ceylon cinnamon stick. Once the water is boiled, I add all of the above teas. The result is amazing!

Hubby used to take the EGCG supplement (4 years ago), but I read about its toxicity, so I had him stop it. I believe we had discussed it here at that time.

[SilentEchoes in reply to Despe]

Thanks for the tip!!

[Despe in reply to SilentEchoes]

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