Withania Somnifera (Ashwagandha) shows ability to counter Parkinson's Disease

[JayPwP]

symbiosisonlinepublishing.c...

Withania somnifera (Ashwagandha) is a very revered herb of the Indian Ayurvedic system of medicine. It is useful for treating various kinds of disease processes and especially used as a nervine tonic. Withania somnifera (Ws) contain a wide array of active components including withaferin A, withanone and other flavonoids exhibiting strong anti-oxidant properties. Many scientific studies on Ws were carried out previously that showed its anti-oxidative effect, synergistic effect with other medicinal herbs and its efficiency to increase catecholamines level and regulation of apoptotic processes. Furthermore, treatment of Parkinsonian mice models with Ws has shown neuroprotection of dopaminergic neurons in substantia nigra pars compacta region of mid-brain. The present review enlightens the crucial role of Indian Ginseng to curb neurodegenerative disorder such as Parkinson's disease. Extensive studies are needed to prove its therapeutic efficacy in neuronal disorders.

[Farooqji]

I take it. Good for stress

[park_bear in reply to Farooqji]

Any effect on your Parkinson's symptoms?

[Farooqji in reply to park_bear]

There are studies that show that Ashwagandha strengthens the muscles and enhances the exercise endurance. That's why it is often used by athletes

[MarionP in reply to Farooqji]

What does that mean?

[Farooqji in reply to MarionP]

A study has reported the efficacy of Ashwagandha root extract in improving muscle strength by exercise based evaluation of muscle strength. The study proposed that extract supplementation reduces exercise-induced muscle injury by downregulating serum creatine kinase levels (Wankhede et al. 2015).

Please read this book "Science of Ashwagandha"

filebin.net/d07eyjmijj92qvq0

[park_bear]

This is a review article summarizing prior work. It appears that the most advanced prior work was based on the usual rodent model of whether the subject compound protected against toxic compounds causing parkinsonism. This sort of model is not very good because it bears little resemblance to mitigation of actual Parkinson's.

[silvestrov in reply to park_bear]

Toxin models were the first models of PD and it is good to have them, but, like PB says, they are not models of idiopathic Parkinson's disease. Regardless of this fact, Mucuna pruriens, which many people use has.............. Synergistic effect of Mucuna pruriens and Withania somnifera in a paraquat induced Parkinsonian mouse model

scirp.org/journal/PaperInfo...

Where did chemical model's of PD come from? openvault.wgbh.org/catalog/...

[Despe]

I also found this study:

researchgate.net/publicatio...

[LAJ12345]

Apparently a lot of sources are contaminated by heavy metals so be sure to source it from a reliable supplier

[Somic67]

I trust anciest indian medicine (ayurveda) sometime more than our modern medicine. Ashwaganda, turmeric, ghee, mucuna, etc don't need to be supported by modern studies. IMMO

[JayPwP in reply to Somic67]

Agreed 100%

[Di01]

Hi is possible that you can get low serotonin levels in parkinson also ?

[JayPwP]

Interesting article

An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda

ncbi.nlm.nih.gov/pmc/articl...

[JayPwP]

Would someone help decode the dosage of ashwagandha to be taken daily?

[Gcf51]

regular ashwagandha extract makes me itch. I take KSM-66

[JayPwP in reply to Gcf51]

Thank you for your inputs.

[Farooqji]

I used ashwagandha for the last 3 to 4 years. For the past one year I have been experiencing sever hair fall. I was unable to pinpoint the exact root cause until I came across a case study of lady diagnosed with hyperthyroidism. She had severe hair fall as one of the symptoms. She had been taking ashwagandha for long time. When she discontinued ashwagandha, everything was back to normal

[JayPwP in reply to Farooqji]

Thank you for your inputs. What was your dosage and did it help with your pd symptoms?

[Gcf51 in reply to Farooqji]

I too have used for years.... I can't say, I am not losing hair... I take (2) 250mg a day of KSM-66.

One article says: Ashwagandha intake has been associated with high levels of DHEA (dehydroepiandrosterone) production. DHEA is a hormone that promotes hair growth. Additionally, DHEA increases collagen synthesis that improves the elasticity of the scalp, and repairs any sun damage. As a result, you get healthy and shiny hair. shazandkiks.com/blogs/read/...

But another says: Men having high levels of testosterone should also abstain from consuming ashwagandha, as it would further increase the level of the hormone and lead to dihydrotestosterone (DHT), which results in early balding. healthshots.com/healthy-eat...

[JayPwP in reply to Gcf51]

What is the difference between ksm 66 and other ashwagandha root extract?

[Gcf51 in reply to JayPwP]

look at their site ksm66ashwagandhaa.com/

[JayPwP in reply to Gcf51]

Thank you

[JayPwP]

youtu.be/CuiiYTgakxY(Not working as expected?)