Wanted to share this information with the board. I have been giving my mother Vitamin B2 (Riboflavin) for almost 2 months now and there is definitely improvement in her energy levels, balance and walking.
She is getting 50mg dose once in hours, 3 times a day (for a total of 150mg/day). Giving it with water in the early morning & late evening and then along with Probiotic in the afternoon. Also, I am giving her vitamin B6 (Pyridoxal 5-Phospate sold by Thorne - 100mg/day - one time).
I know the trial related to Vitamin B2 used a 33mg dose, 3 times a day and showed a month- over-month improvement in motor symptoms that continued for almost 6 months in a few, while most of them had that sustained improvement over a 3 month period.
Best wishes for a HAPPY NEW YEAR.
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John_morris71
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Up to our knowledge, there is only one clinical trial that studied the effects of high dose riboflavin on PD patients. This study used an oral dose of 30 mg riboflavin every 8 h, in combination with the usual symptomatic treatment of PD, for a 6-month period in 19 patients with PD and low-riboflavin status despite normal general nutritional status (98). Since PD patients have higher consumption of red meat in comparison with healthy controls, dietary red meat was eliminated during this 6-month period study (98). Enhanced motor capacity was noted in all subjects in a progressive manner that reaches a plateau during the first 3 months of the study; while in 5 out of the 19 subjects, motor capacity continues to recover in every month in the 6-month period (98). In this study, motor capacity enhanced from 44 to 71% in average (98). 100% motor capacity has been reached by three patients within the first 3 months of this study (98). However, a consideration was raised by a commentary on this paper (99). Ferraz et al. has pointed to the effects of low-protein diet on enhanced levodopa absorption (99). According to the commentary, the improved motor capacity in those patients could be the result of the enhanced absorption of levodopa rather than the administration of riboflavin (99).
Conclusion
Riboflavin is a potential neuroprotective agent. In fact, riboflavin has demonstrated its ability to tackle significant pathogenesis-related mechanisms in neurological disorders, exemplified by the ones attributed to the pathogenesis of PD and migraine. Indeed, riboflavin ameliorates oxidative stress, mitochondrial dysfunction, neuroinflammation, and glutamate excitotoxicity; all of which are involved in the pathogenesis of a wide range of neurological disorders. In addition, riboflavin is required for pyridoxine activation. Riboflavin and PLP, the active form of pyridoxine, play essential roles in homocysteine metabolism, and tryptophan-kynurenine pathway. Indeed, any accumulation of homocysteine or kynurenines due to vitamin insufficiency can lead to significant neurological consequences. Taking into consideration the limited riboflavin absorption and utilization in 10–15% of global population, long term riboflavin insufficiency could participate in the development of multiple neurological disorders, emphasizing the importance of long-term riboflavin-sufficient diet especially in vulnerable populations. Indeed, randomized double-blind placebo-controlled trials, with extended time frame and large number of patients, are encouraged to clinically evaluate the role of riboflavin in PD and migraine headache patients.
And here I am trying to figure out how to cut down on my supplements. Thanks!
Thank you for that John. I had read about B2 being useful in PD, but yours is the first actual report I have seen, so good to know that your experience with your mother and the study seem to mirror each other. Improvements in quality of life are music to the ears!
I would like to see if she can replicate the month over month improvement after 5 to 6 months that a few of them in the trial experienced. It is going to be almost 3 months in another 2 weeks. Keeping fingers crossed.
She is using Kefir on a daily basis since more than 4 years. (Lifeway brand, once a day 200 ml that has more than 10 different strains of beneficial bacteria).
Other than that I have given her Kombucha, BioKult, Yakult, Symprove, Multibiotics Active - Activ Health Brand, etc., each for a few months, to supplement the daily dose of Kefir.
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Interview of Daphne Bryan following the publication of her book: “Parkinson’s and the B1 therapy”.
B1 and Vibrating gloves combination
Does anyone take Vitamin C with each Sinimet (C/L) dose?
Important question: Reduction of B1 over time is inevitable, but how far does this go?
A good article on HDT 
