I am from Mumbai, India. I have Parkinsons and liver disease as well.
I am on various facebook groups. There people recommend using Allithiamine TTFD.Its a disulfide derivative of Thiamine...
Thiamine Hcl i have tried but it doesn't penetrate the brain.. No effect.
Now about Allithiamine its that when the disulfide bond is broken to metabolize it, the body uses Glutathione. So glutathione is depleted. Now Glutathione is very essential for the liver for detoxification. Again to replenish the Glutathione, the body uses vitamin B2 riboflavin. The downside with TTFD is it depletes glutathione and Vitamin B2.
So there was a famous biochemist Andy Cutler of the Chelation protocol fame. He said TTFDs are hepatotoxic because of the free sulphur thiol it creates. He was against TTFD use calling it severely hepatotoxic.
On onibasu. com, there are his transcripts where he says TTFD is hepatotoxic.
Does anybody know if TTFD Allithiamine could be used low dose say 25/50 mg in Liver disease?
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amit74
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Sorry Amit, too advanced for me. There are smart people here with different backgrounds and hopefully you'll get some solid advise. Good luck and be well.
I know its website by Dr Derrick Lonsdale and Chandler Marrs.. i am in their group too on Facebook... They advocate it.. But look at onibasu.com archives.. You would find transcripts of Dr Andy Cutler and Susan Owens in a fight over TTFD safety.. Those conversations on yahoogroups are of the year 2003-2004
These are the onibasu. com links.. There are many links on each page.. If you click on it, a new page opens. It gas many links again.So each page has the quarrel between Andy and Susan plus links to other pages on TTFD.. He says categorically its poison and advises parents to stop prescribing TTFD and use Benfotiamine instead..
Benfotiamine can't cross the BBB. It's good for peripheral neuropathy that I have read about. My husband takes Sulbutiamine, 200mg, once a day. He has been on all forms of B1, including B1 HCL, when he was first diagnosed 4 years ago, and he really did great. He is just experimenting with various forms of B1. Never had liver problems.
Sorry, meant Art OR Rescuema. They are two forum members very knowledgeable. Search "Thiamine" on this site, upper right-hand corner "Search HealthUnlocked."
I have taken everything Allithiamine, Sulbutiamine, Thiamine, Benfotiamine... i have everything with me.. The way Allithiamine and Sulbutiamine work is similar. They both are disulphide derivatives. The disulphide bond needs to be broken. Glutathione is depleted... If you search Sulbutiamine on wikipedia, you wud see it mentioned- Cysteine or Glutathione used to break the disulphide bond
nnjournal.net/article/view/... I am a pop and a physician . I have been researching the connections between liver dz and PD . on topic link but not exactly what your looking for but may be of interest.
My question is If i use Allithiamine 50 mg daily (thats the lowest dose available), it it likely to cause hepatotoxicity in just 2-3 months? In the UK, you have Thiamax.. Thats Allithiamine and it comes pure without any fillers... There is so much of research on Allithiamine /Fursultiamine in Japan.. Theres no research in the western world. In fact, it was first made in Japan in 1960s to treat Beri Beri.. Fujiwara did lots of research on it.... It is sold OTC in Japan as Alinamin, Alinamin-F by Takeda pharmaceuticals
They are patented forms of b1 and all research has been sponsored directly or indirectly. All of these new forms of thiamine have been at the center of trade wars in the past, what you find is the product of this. The greatest expert on thiamine is Lucien Bettendorf. Here is a previous discussion that might help you.
I emailed to Lucien Bettendorf a few days ago giving links to his own research on Allithiamine TTFDs etc and asked him a question . He replied saying I have never researched TTFDs and Allithiamine.. I only have researched Benfotiamine.. Ha ha ha... Are you able to believe this? I have the email with his reply...
But why use TTFD. when you can use thiamina hcl without any problems? I have been using it for six years 100 mg Intramuscular injection 2 times a week, no problem.
Here's how I see it. The problem with fat loving thiamine derivatives is that it stores and collects in your adipose tissue regardless of whether you need it or not, and thus can create an overdose which can keep building and keep building once it is there you basically have to process it to eliminate it. Thus it is really only useful for people who have an outright thiamine deficiency, safer in the case of chronic deficiency. One cannot really dos up safely in order to address dopamine depletion or lower dopamine production that we find in pwp. You are much more likely to go toxic long before you could reap much or any PD benefit at all.
Water soluble B1 (thiamine HCL) has no such similar toxic buildup risk, because you absorb as much as you can which allows you to get into the upper dose reaches that seem to help so many over a time of sustained dosing over months and years in people whose PD is not too far advanced to benefit, and then the rest is happily excreted, without requiring nearly as much processing energy and metabolic and storage resource. This allows for the strategy of dosing up into high doses to reap the benefit without significant risk. You need to look up the work of Dr Costantini in this website. The main risk is limited, basically to a few flushing-irritation side effects when one exceeds the limits of personal tolerability.
There are a number of potentially very serious side effects and at least very disruptive side effects associated with these fat soluble synthetic versions that one does not run with the water soluble thiamine HCL... Honestly I don't know why anybody would really want to use any of the benfothiamine or allothiamine type of fat soluble synthetic derivatives, they seem to be mostly risk with little prospect of benefit and rather little research support. You would need a very good reason to get me to use a fat-soluble thiamine, and I've yet to see one.
I am asking about a low dose of Allithiamine say 50 mg daily..Thats the lowest dose available. Is that likely to cause hepatotoxicity ? lets say i use it for just 2 months.
Also as Dr Costantini used very high doses of Thiamine Hcl.. Dont they deplete vitamin B2 and maybe other B vits.. Because if Thiamine Hcl of the order of 2g is being taken daily without any other B vits, it would obviously cause a deficiency of other B vits
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