Allithiamine vs Thiamine

[YoungPSP]

I have read multiple articles regarding the utilization of Thiamine for Parkinson's, there appears to be a discrepancy regarding whether Allithiamine or Thiamine HCL is a better product. Does anyone have an opinion as to which product is better and why?

[park_bear]

It is about which is most appropriate for a particular purpose. For the high-dose protocol thiamine HCl is used because it is water-soluble so the body can easily dispose of the excess.

[Gioc]

Topic covered a dozen times here. This research tells us why not to use benfothiamine which is not allithiamine.

ncbi.nlm.nih.gov/pmc/articl....

IMHO is a matter of practicality and safety, thiamine HCL is the most available, inexpensive and water soluble, i.e. excess is quickly expelled from the body.

link.springer.com/article/1...

[Despe]

Derrick Lonsdale MD, FACN, CNS

hormonesmatter.com/thiamine...

Thiamine HCL is water soluble, Allithiamine is lipid soluble, both B1.

[MarionP]

Lipid soluble collects in adipose tissue and may thereby become toxic overdose. Avoid.

[chartist]

YoungPSP,

All of the above and then some.

When you understand Dr. Costantini's situation it starts to make sense why he did not test other forms of thiamine or if he did I don't remember him mentioning it, but it has been awhile so he may have mentioned it and I just forgot about it. He did mention benfotiamine as not recommended I believe. Since he essentially had clients all over the planet due to his email patients, he wanted something that would likely be available to as many people as possible and effective. Thiamine/B-1 fits that description well. It does not mean it is the best or most effective, it just means that it was Dr. Costantini's first choice after the injections and availability probably played into that decision.

Art

[rescuema]

I prefer Allithaimine (TTFD, not to be confused with Benfotiamine) because it directly crosses the blood brain barrier. Since it crosses the lipid barrier, it gained the reputation as fat soluble but it is in fact water soluble and not toxic to the body. You may not absorb the thiamine hcl if you lack the transporter activities or genetically compromised, and only through a very high dosage of B1 hcl it can cross the BBB through passive diffusion when the serum level is very high.

[YoungPSP in reply to rescuema]

I really appreciate the response, what dosage do you utilize?

[rescuema in reply to YoungPSP]

It depends on a person and what it's for. If you're trying it for PD, it may be better to try the B1 Hcl route as the rest of the patients of Dr. C's to relate to the general population experience here starting with 2-4g per day depending on your weight (see the below FAQ link), but as far as I understand Dr. C doesn't object to people using TTFD although you won't have as many reference points. TTFD is not toxic and since it does not depend on enzyme transporters, you can titrate up slowly staring with 50mg per day for a week and gradually increase weekly as high as 300mg or more per need while watching for paradox healing reactions.

Always be sure to supplement magnesium since it is a required co-factor and also include a good methyl b-complex since all B's work in concert or you'll go deficient in one with overdose of another.

healthunlocked.com/parkinso...

hormonesmatter.com/ttfd-thi...

[Despe in reply to rescuema]

Rescuema,

I have been searching for B1 hcl sublingual, 100mg. I can't find this type, do you know of any on line seller of this specific B1? Thanks!

[rescuema in reply to Despe]

I believe this is one of the sublingual used by the PWP on this forum. I've never tried it.

amazon.com/Superior-Source-...

[Despe in reply to rescuema]

Thanks! Yes, I found it, too, but if I am not mistaken, there is an HCL version (the linked one is mononitrate).

[rescuema in reply to Despe]

The last time I looked into people taking sublingual, it was the mononitrate form.

healthunlocked.com/cure-par....

[Lizzy9 in reply to rescuema]

Hello ~ I've just come across information on TTFD and I'm wondering if it would be a better choice for my HwP. He is currently on 75 mg of the Mononitrate B1. We just couldn't find a correct dose of the regular HCL.

I am wanting to try another form since it seems like some of his symptoms have increased, tremor and anxiety. I had him take a holiday, stied the sublingual Mononitrate and just couldn't get the dose correct. He is better since we increased the Mononitrate to 75 mg in 3 divided doses and we skip one day a week. We have so recently changed to this dosage that I am still toying with whether or not to only give this dose 5 days a week or 6.

Anyway, I was wondering if you had any suggestions about how to go about switching or if a combination of the two would be a better option.

Thank you for your time and help. Have a fabulous day!

Gail

[rescuema in reply to Lizzy9]

Hi Gail,

It's tough to say whether other forms will be better or not, and it really would depend on the individual and nutrient status. The only way to find out is to try it. Please see my relevant reply below on another thread.

healthunlocked.com/cure-par...

[Lizzy9 in reply to rescuema]

Thank you for responding. I just watched the video. Needless to say I will be watching it again. All of this is such tricky business!!!

Thank you again and have a fabulous day~

Gail