What has been the experience of members ... - Cure Parkinson's

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What has been the experience of members who have trialled sublingual thiamine nitrate (from a new member)

bloodbrainbarrier profile image

Many have tried oral high dose thiamine HCL with a range of benefits while sublingual thiamine nitrate is also reputed to have beneficial effects for some.

17 Replies

Thiamine Mononitrate has been discussed on this forum a bit. Here is a link to some of those discussions:

healthunlocked.com/search/p...

I take it for its Th-17/IL-17 potent inhibiting effects at relatively low dose.

Art

Thanks Art for your reply - I found it very useful.

You're welcome, bbb!

Art

My husband had his B1 levels tested and for him they were normal, so he has focused more on what what out of range for him (uric acid, vitamin D and vitamin B12). He isn't done with his lab tests yet so there might be more for him to focus on in the future, but so far B1 seems fine as is in his case.

bloodbrainbarrier profile image
bloodbrainbarrier in reply to

Thanks for that, Brenda.

rescuema profile image
rescuema in reply to

Serum test will not reveal B1 deficiency in the brain and normal diet/supplementation of B1 will not restore the deficiency as the result of deficient thiamine transporter. The way around this is through very high dose B1 hcl (passive diffusion) or through B1 derivatives such as TTFD/Allithiamine (crosses the BBB) and Benfotiamine that restore the transporter function through high bioavailability. Look into B1 supplementation. You may get pleasantly surprised.

hormonesmatter.com/energy-d...

ncbi.nlm.nih.gov/pmc/articl...

chartist profile image
chartist in reply to rescuema

Very well said and concise, Rescuema!

Art

Thanks very much for that information, Rescuema.

I have taken sublingual B1 since 2017 with great success. Within a couple of months rigidity went, facial expression returned, walking improved, bradykinesia improved, and no increase in medication for five years.

Zardoz profile image
Zardoz in reply to Dap1948

Dap1948,Can you be sure that it was the B1 mononitrate and not something else that caused the improvement? Was it a doctor that advised you to try high dose B1?

Dap1948 profile image
Dap1948 in reply to Zardoz

I can be sure that it was the B1. I trial only one thing at a time and keep a thorough symptom diary. I even stopped it for four months. Initially fatigue re-emerged, but after three months, rigidity started to come back and slowness. I went back on the B1 and all was well again within a few weeks. It did happen to be a doctor who told me about B1 and the work of Dr Costantini, however he was a friend with PD, a retired doctor but not my doctor. My doctors and neurologist, while being staggered that in my 12th year since diagnosis I have so few symptoms, are only mildly interested in what might have caused this.

chartist profile image
chartist in reply to Dap1948

That was a very good summation, Dap!

Art

Zardoz profile image
Zardoz in reply to Dap1948

Thank you, that's encouraging. I've been on sublingual thiamine mononitrate for a full week now based on your endorsement, but have yet to see some positive results.

But you did write that it took months to get improvement.

Dap1948 profile image
Dap1948 in reply to Zardoz

One of my problems was I didn’t notice the improvements myself. I remember smiling one day and thinking “this feels different” and another day while having a massage I thought “gosh I’m sinking deeper into relaxation than normal”. Then I went out more and joined things and it still didn’t dawn on me that it was because I had more energy. Then my friends started to tell me I was looking better and was moving better... dah! Good luck to you

JMSL profile image
JMSL in reply to Dap1948

May I ask what dosage & brand of sublingual B1 you are using, Dap1948?

Dap1948 profile image
Dap1948 in reply to JMSL

pureformulas.com/no-shot-b-... started on one tablet a day. See my post on how to take sublingual tablets. I reduced very gradually in my second year and now take 4 tablets a WEEK.

Dap1948 profile image
Dap1948 in reply to JMSL

This is the ‘how to take’ posthealthunlocked.com/cure-par...

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