Cocarboxylase form of b1 -- would this be okay to use?

[kathy775]

I'd like to try to get my dad, who has Parkinson's, started on b1 therapy soon enough ... I understand thiamine hcl is the form advocated by Dr. Constantini. I'm just wondering, does anyone know of the cocarboxylase form of b1 or have experience taking it, and knows if this has adverse effects over time? I am not scientifically inclined ... I saw a brand that carries the sublingual form of this: pureformulas.com/coenzymate...

[sharoncrayn]

ThPP or TDP ...the active co-enzyme form of B-1. Formulated for quick action and uptake.

I doubt whether Dr. C used it, but I am no expert on his protocol. Usually given as an injection. When oral, dosed usually as a sublingual.

Several oral brands. Usually 16-20 mgs/tab. Way, way, way, way below Dr. C's recommended dosing.

Most B-1 is water soluble (but not all forms). Very rarely toxic even with the synthetics.

Don't really understand your interest in this B-1 form. Why?

Better to start your thought process by searching for and reading Dr. C's Q and A post(s).

sharon

[kathy775 in reply to sharoncrayn]

Thank you for your reply, I appreciate it. I know that Dap1948 has used a sublingual form (thiamine mononitrate) with success over the years, and that the sublingual or injectable forms are much better absorbed by the body (doesn't need to go through the gut). I've already purchased the Vitacost thiamine hcl capsules and sent them over to my dad, but he lives in Asia (I'm in Canada) and he is with my mom, who is against natural supplements and basically has stopped him from taking anything other than the PD drugs up until now ... even things like Vitamin C or D. The reason I'm looking into sublingual forms is that maybe smaller tablets of b1 would be less conspicuous (to my mom). Of course, I'm considering efficacy and possible toxicity. The doctors have got him on the equivalent of Madopar, and since January, they started him on ropinirole, but it sounds like the ropinirole has really affected his head and I'm afraid of him suffering other side effects. The mononitrate version, I understand, has a very strong taste, while this version is more palatable, according to reviews. I have read some of Dr. C's posts, but didn't read through every one ... I will review it. Thank you kindly for your suggestions.

[chartist in reply to kathy775]

Kathy,

The HCI form of thiamine is much much more bitter than the mononitrate form or at least that is the case for the version that Dap is taking. Also, as Dap related to me in a previous post, the mononitrate version taste, you adjust to fairly quickly and I would have to say she is correct. At first I was taking them with a peppermint Altoid to mask the taste of the thiamine mononitrate, but now it is no big deal and I don't need to take an Altoid with it any more, but I also don't get to close to other people for awhile after taking it.

On a related note, forum member Lizzy9 also found the mononitrate form of thiamine significantly more effective than the HCI form of thiamine for her husband with PD. You can read about their experience in this other thread :

healthunlocked.com/cure-par...

Lizzy9 starts her series of replies just past half way down the page where she starts discussing how her husband is doing on thiamine HCI and then later relates how he did on thiamine mononitrate and then further relates how he is doing after switching back to thiamine mononitrate again. Interesting reading for anyone on or considering thiamine HCI .

Art

[kathy775 in reply to chartist]

Art, thank you kindly for sharing your experience and for pointing me to the thread with the feedback from Lizzy9. I really appreciate it!

I'm glad to hear the taste of the mononitrate form is not so hard to get used to ... I will try ordering it for my dad! The Altoids trick is great too.

Yesterday (before I saw your reply), I also saw a sublingual B1 product based on thiamine hcl (BariMelts B1 berry flavour) and had also ordered it (it is on Walmart and Amazon), but some reviews say that tastes bad too (whereas some say it tastes fine).

I will ask my dad to try the sublingual forms and compare how he feels.

Many thanks!

Kathy

[chartist in reply to kathy775]

Kathy,

It takes a moment to get used to the mononitrate sublingual version, but I seemed to after the first two bottles. I think it gets even easier if you start seeing benefits too! Keep us posted on how your dad does with it.

Art

[Always_hope in reply to sharoncrayn]

The HCL did not work well for my hwp. He is finding that the sublingual tablets cocarboxylase or mononitrate is much better. He is also taking some Benfothiamine

[Always_hope in reply to Always_hope]

It's the same for my hwp

[kathy775]

Thank you so much, Art ... have a lovely day!

Regards,

Kathy