Agmatine is a compound naturally formed from the amino acid L-arginine. It is a neurotransmitter found predominantly in neurons. Because it is capable of targeting multiple receptors, researchers are investigating it in the context of a spectrum of complex diseases.
— Block NMDA receptor: Agmatine binds to 2 sites of the NMDA (N-methyl-D-aspartate) receptor and prevents glutamate from binding to them. This may prevent neuron death from overexcitation due to the neurotransmitter glutamate
Johns Hopkins researchers have discovered that nitric oxide, a chemical messenger involved in bodily functions from erection to nerves' communication, also shuts down a protein involved in Parkinson's disease.
Agmatine is a NMDA receptor agonist like Huperzine A. Been a few months, that’s how I remember it anyways. Huperzine A is more powerful so I bought it a few months ago but have not tried it yet.
Here is a link to that discussion. I think it might contain the same video. I like Leo.
As per Leo, Huperzine A is a weak NMDA antagonist compared to other molecules.Nitric Oxide is normally high in chronic diseases. I think one of the possible effects of HDT is to reduce Nitric Oxide and that cause hypertension in some people.
Vitamin B2 can also affect NO.
Hydroxocobalamin reduces NO.
Arginine increases NO.
Some people with Migraine gets better with taking B2 or Arginine.
Does Agmatine increase NO too? I think Arginine is a precursor to Agmatine. NO is still confusing to me. It is implicated in causing ALZ but it is also very important for memory formation and is important for vasodilation.
Agmatine Suppresses Nitric Oxide Production and Attenuates Hypoxic-Ischemic Brain Injury in Neonatal Rats
Agmatine appears to block the production of NOS (nitric oxide synthase): There are 3 main enzymes that produce nitric oxide (NO); iNOS, nNOS, and eNOS:
iNOS (inducible) produces large quantities of NO as a function of the immune system to kill harmful bacteria. If left unchecked, iNOS can cause inflammation.
nNOS (neuronal) is a signaling molecule that facilitates communication in the brain across neurons. If left unchecked, nNOS can inhibit the growth and repair of neurons.
eNOS (endothelial) signals vasodilation in the lining of blood vessels for increased blood flow. Increased blood flow lowers blood pressure and increases the import of oxygen and nutrients and export of cellular waste products.
Thus, some researchers believe agmatine may regulate nitric oxide levels by inhibiting iNOS and nNOS and increasing eNOS.
Thus, some researchers believe agmatine may regulate nitric oxide levels by inhibiting iNOS and nNOS and increasing eNOS.
Thank you! I’m going to have to revisit this when I can better focus. (Busy day) But as of now I’m confused as to why Leo mentioned Huperzine A? I’m definitely missing something.
I bought Huperzine A a few months ago but I thought it was related to the phosphatydl choline action. (Totally messed up that spelling) this is too deep for multi tasking but it’s what I’d much rather be doing.
Leo is saying actions of the molecules like Huperzine A on 3 different aspects, on NMDA receptors, on Acetylcholinesterase enzyme and Nicotinc receptors in the brain. If I recall correctly, Leo concluded that Huperzine A has less affinity to NMDA receptors than the others plus has no negative effects on nicotinic receptors.
I think I bought the Huperzine A when researching nicotine and wanting the benefit of it without using nicotine. I believe the prescription drug donepezil works in the same manner but is much stronger. Are you considering trying Agmatine?
It looks to be very widely used.
I do not know about interactions and if it is complimentary to Huperzine A
The main reason is that if I take anything that reduces activity of Acetylcholinesterase enzyme then my dystonia may back again. With the same reason I cannot take supplements containing Choline.
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