Has Anybody Figured Out How to Get Farnesol?

[Bolt_Upright]

Waiting for PARIS—A Biological Target in Search of a Drug 2022 content.iospress.com/articl...

[House2]

ncbi.nlm.nih.gov/labs/pmc/a....

[House2 in reply to House2]

researchgate.net/figure/Div...

[Bolt_Upright in reply to House2]

Thanks. I was hoping to get powdered or liquid food grade.

Plant Sources of Farnesol

[Gcf51]

I emailed doTerra asking. They replied present in some of their essential oils but not in significant quantity in any of their products. Best, I can tell it would require refrigeration or a whole lot of preservatives.

[Bolt_Upright in reply to Gcf51]

I don't think the essential oils are edible. Thanks.

[SilentEchoes in reply to Bolt_Upright]

Diffuse or mix with a carrier oil for topical application. Transdermal is a great way to get medicinals into the body. If you have pets you have to be very careful with the oils you use, some are toxic to them.

SE

[Bolt_Upright]

Wow. I searched "food grade farnesol" and found some. I'm not sharing the link, but I will share the warnings:

Hazard Statement: Causes skin irritation. Causes skin and eye irritation. May cause an allergic skin reaction. Causes serious eye irritation. Toxic to aquatic life. Toxic to aquatic life with long lasting effects. Precautionary Statement: -PREVENTION- Avoid breathing mist or vapor. Wash thoroughly after handling. Contaminated work clothing should not be allowed out of the workplace. Avoid release to the environment. Wear eye protection/face protection. Wear protective gloves.

-RESPONSE- IF ON SKIN: Wash with plenty of water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If skin irritation or rash occurs: Get medical advice/attention. If eye irritation persists: Get medical advice/attention. Take off contaminated clothing and wash it before reuse. Collect spillage.

-STORAGE- Store away from incompatible materials.

-DISPOSAL- Dispose of contents/container in accordance with local/regional/national/international regulations.

[Gcf51]

doTerra says many of their products can be diluted and consumed. I have take their Turmeric. My experience 1 drop in a cup of coffee is not enough buffer. While trying to gain weight I mixed with a protein shake.

[Bolt_Upright]

Well this is interesting. A food compound database!

Showing Compound Farnesol (FDB014891)

foodb.ca/compounds/FDB014891

Scroll down to "Associated Foods" and you will see which foods have Farnesol (and how much). Some highlights:

Ceylon Cinnamon! .75 mg per 100 grams

Cumin! 83.400 mg/100 g (that's almost a milligram per gram!)

Pot marjoram 4.500 mg/100 g

I don't think I can eat that much cumin.

[JAS9 in reply to Bolt_Upright]

How about this?

vitacost.com/amazing-herbs-...

[Bolt_Upright in reply to JAS9]

Interesting and thanks. When they said Cumin I don't know if they meant the Mexican food spice Cuminum cyminum or Nigella Sativa. Doing a little Googling it looks like Nigella Sativa has a tiny amount of Farnesol (maybe 2%). Cuminum cyminum has Farnesol too. I have about 6 grams of ground Nigella Sativa a day, so hopefully that is giving me some.

[JAS9 in reply to Bolt_Upright]

It's not very water soluable. Do you mix it with EVO oil?

[Bolt_Upright in reply to JAS9]

I grind it in my coffee grinder and eat it (heaping teaspoon mixed with a heaping teaspoon of Ceylon Cinnamon and 600 mg of licorice extract) with a spoon. I chew it to hopefully release the magic.

[Hidden]

Lemon grass? Citronella?

researchgate.net/figure/Div...

[Hidden]

Can our skin absorb it? This reputable company has many products eith it.

weleda.com/ingredients/ingr...

[Bolt_Upright in reply to Hidden]

Somebody messaged me that they tried rubbing farnesol oil on their skin and had a bad reaction.

[Hidden in reply to Bolt_Upright]

I sent a link above of a skin care company from Germany that uses it in a lot of products. They are a good company

[PDTom in reply to Hidden]

Farnesol - you can get it from Merck in synthetic form. This is used in foot balm, for example. Is it here in Germany. I ordered it from Merck! - However, it was not delivered - only to pharmacies, etc... I could probably organize to get farnesol - but I also wrote to the responsible professor, who said it had to be changed for food intake. But they also fed the mice with it back then! Do we have to wait another 10 years for more information? The lobbyists and the pharmaceutical industry are probably behind it. Nobody wants to lose their source of income. In the end it may be the poorer countries like Cuba (they are also researching Parkisnon - even quite successfully!), South America or Asia that will implement the discovery with farnesol or other simple "natural substances" more quickly. I had thought about contacting a food chemist or a laboratory that would produce farnesol for me in such a way that it could be eaten. But if it were that easy someone would have had to do it - right?

[Hidden in reply to PDTom]

Do you know if the skin absorbs it well?

[PDTom in reply to Hidden]

I don't know, but there are also nicotine patches...

I come from the construction industry so I know my way around better!

As I said, it is incomprehensible to me that farnesol is not examined much faster! As I read the article at the time, I thought they would go full throttle now! I try to follow developments in Parkinson's research around the world. But you don't really hear anything about farnesol anymore.

[JAS9 in reply to PDTom]

Many scientists have been working on it, but the effort is not being funded by big pharma. Still, there is funding, and you can read about it.

"As part of our effort to bring novel disease-modifying therapies to the Parkinson’s community, Cure Parkinson’s is urgently exploring taking farnesol into safety and dose-finding evaluations to progress its clinical development. To this end, the research team at Cure Parkinson’s have written a paper outlining the drug screen to discover farnesol, the relevant Parkinson’s research within the wider drug class, issues surrounding its future formulation, and importantly, the next steps in translating this new knowledge into the clinic to evaluate possible long-term benefits for people with Parkinson’s."

Go here to read more:

cureparkinsons.org.uk/2021/...

[PDTom in reply to Hidden]

The most elegant would of course be a natural product that is edible and contains a lot of farnesol.

But I had also read a small study where different oils (I think it was rosemary oil, etc...) which massaged in improved Parkinson's... Perhaps the oils contained farnesol.

[CPT_Helen Partner]

There are key questions we need to resolve with Farnesol - critically, formulation that is safe and dose of that formulation before we can begin safety testing and then trials to test efficacy. We are working on it.

[Surfdoc1]

Everything I read says berries are the best source for Farnisol. Am I missing something

[Bambin]

I bought a bottle of Farnesol (oil) off Amazon. Chickened out taking it, I mistakenly assumed some guidance would show up on the internet. Settled for enjoying lemongrass as a tea. Nothing to report as far as sympton relief.

[Myfatcat]

Says on the data sheet "III. Assessing Risks to Human Health

No adverse effects are expected in humans from pesticidal use of these active ingredients. They are

naturally present in many foods we eat, and approved as food flavorings by the Food and Drug

Administration (FDA). The chemicals also showed no toxicity in animal tests." Can't be that bad, although it tastes like crap. 100ml is about $20 from Germany. Sala Chemical. salandia.com

I am getting up the courage to take a big slug.

Dennis Owen

[Bolt_Upright in reply to Myfatcat]

Pesticidal use means pesticide residue exposure. This is not the same as drinking it. PLEASE CONSULT AN EXPERT before drinking this stuff.

[Bolt_Upright in reply to Bolt_Upright]

"Causes skin irritation. May cause an allergic skin reaction. Causes serious eye irritation"

[Bolt_Upright in reply to Bolt_Upright]

"General:

Farnesol - has an antibacterial effect, especially against bacterial sponges that are responsible for breaking down sweat and the associated smell of sweat.

Areas of application:

Deodorant, foot spray and deodorizing washing emulsions

Use concentration:

0.3 - 0.5%"

This should not be ingested. It is supposed to be diluted before using at all.

[Myfatcat]

Too late, I swallowed one half tablespoon( 7.5 ml). 98% pure. No noticeable effects. peppery taste. May be a problem to swallow because it triggers a gag reflex in me , but still doable. I could put it in capsules and hope they don't break or leak. I wonder if I should skip the C/L for the day.

[Myfatcat in reply to Myfatcat]

Re: Farnesol I don't consider risky to ingest the neat liquid. It is a fragrance and FOOD additive. (mentioned several times in literature.) Last month I completed a seven day course of neat Farnesol, 2ml per day (just a dart board guess). I filled gel capsules and carefully slid them back together. This procedure took care of the bad taste around the outside of the capsule and indigestion that might occur. The gel caps were vegetarian and not gelatin. They were a little sticky after 24 hours, so I filled them and swallowed them same day. I used the biggest capsules I could find ("000"). I did not discontinue C/L during this work.

Unfortunately I didn't observe any effects from this trial. I probably need higher dose or longer trial. But I will consult with an authority before taking any more. Even though I am a graduate chemist I should have consulted with a more knowledgeable person. Bolt, you were right.

Dennis

[Hidden in reply to Myfatcat]

Very interesting! Would you mind sharing where you acquire the farnesol and capsules? (The moderators who ignore requests for help will likely reappear to pounce on this discussion)

[Bolt_Upright in reply to Hidden]

Please read my posts directly above and be careful.

[Bolt_Upright in reply to Hidden]

We are still at mouse models for Farnesol. Fairly speculative territory. We should make a ranking of supplements based on strength of evidence. I would put Niacin, Berberine, Vinpocetine, and PEA near the top of that list.

[Hidden in reply to Bolt_Upright]

Agreed. But I think Ginkgo might might be better than Vinpocetine. Please see my post about coffee. I’m going to resume eating / drinking unroasted coffee Curious about your opinion.

Oh and why is wine said to improve glymphatic drainage? I need to dig in to that.

[Bolt_Upright in reply to Hidden]

I was just reading your post on coffee. I don't put too much stock in the studies on things that might help prevent PD. I mean, I put SOME stock in them, and if they fit with what I want to do I veer their direction, but I would not change my life to incorporate them. That said, I don't really know enough about coffee to weigh in. I know I kept going back to black tea based on this type of information and I finally stopped again. I love sweet tea, the kind I used to drink before I started fighting in my sleep and was not obsessed with my health. Tea with honey is okay, but I can't drink just one and it puts me on a caffeine roller coaster and makes my RBD worse.

Why Ginkgo over Vinpocetine?

Vinpocetine regulates levels of circulating TLRs in Parkinson's disease patients 2019 pubmed.ncbi.nlm.nih.gov/303...

" Methods: Eighty-nine Parkinson's disease patients and 42 healthy controls were recruited for this study. All patients were randomly assigned to either the traditional therapy group (T PD group, n = 46) or the vinpocetine group (V PD group, n = 43), in a blinded manner. Both treatments were administered for 14 days.

Results: Administration of vinpocetine reduced mRNA levels of TLR2/4, as well as protein levels of the downstream signalling molecules, MyD88 and NF-κB; moreover, it lowered the expression levels of serum inflammatory cytokines, TNF-α and MCP-1. Notably, vinpocetine increased TLR3 mRNA levels, as well as protein levels of the downstream signalling molecules TRIF-β and IRF-3, and serum levels of the anti-inflammatory cytokines IL-10 and IL-8. Furthermore, vinpocetine produced a robust increase in the Mini Mental State Examination score, compared to that achieved by using levodopa therapy.

Conclusion: Vinpocetine treatment may exhibit anti-inflammatory activity and alleviate cognitive impairment. "

Targeting PDE1 for PD 2018 scienceofparkinsons.com/201...

"A drug called Vinpocetine (a phosphodiesterase 1 inhibitor) was the only phosphodiesterase inhibitor that reduced alpha synuclein toxicity. Vinpocetine is a synthetic alkaloid derived from the periwinkle plant. It is synthesised from a molecule called ‘vincamine‘.

Vinpocetine is not FDA approved for therapeutic use."

[Hidden in reply to Bolt_Upright]

Chlorogenic acid, a polyphenol in coffee, protects neurons against glutamate neurotoxicitypubmed.ncbi.nlm.nih.gov/262...

[Astronomer90 in reply to Myfatcat]

Where did you get the Farnesol?

[Router_]

So I did look into farnesol as well over the last couple of months. I have not been diagnosed with parkinson's, my case is more of an atypical parkinson syndrome it seems which is why I might be little more eager and risk-taking given the dire outlook.

There is another study done on mice that showed beneficial aspects for the treatment of MS. So in general, there is evidence that it might be neuroprotective.

dc.ewu.edu/cgi/viewcontent....

The dosing in this study was significantly lower than in the PD Mice study.

"Mice induced with EAE and given a daily oral gavage of farnesol 100 mg/kg body weight solubilized in a vehicle of corn oil"

I read up on dose conversion from mouse to human equivalent which said to divide by 12.3 which would put me at around 650mg per day.

The Mice PD study was using 5g/kg of body weight. By that calculation it would be 32g human equivalent at 80kg body weight. I might be risk taking but not that much So I settled on trying the 650mg dose over the course of 2 months.

"Given that Farnesol is hydrophobic, so cannot be dissolved in water, its safety in patients will need to be determined at whatever the most effective therapeutic dose might eventually turn out to be. Lumbar punctures will be needed to verify blood brain barrier penetrance. Thoughts immediately turn to what formulation might best support the dosing regimen. It might be possible to use a shaken suspension or to dissolve it in oil (although that might prove challenging to drink). It is unlikely to be well absorbed by the gut, but that also needs to be determined."

None of the studies mentioned any reformulation of farnesol. I mixed the 650mg with corn oil and drank it. I tested before whether I had any skin reaction from topical application. I did not. I also did not start with 650mg but approx. 250mg for a couple of days before increasing the dose.

I did not see any immediate improvement of my symptoms, but that is not my baseline expectation, which would only be slower progression or maybe some relief. I do have the impression that my gut symptoms have improved and sleep is better. Flare-ups of sebhorroic dermatitis still occuring and some other symptoms have also gotten in worse in that timeframe.

My stack is quite large so it will always be difficult to know if anything is working and if so, which one. I take UMPEA, Melatonin, Ubiquinol, NAD, ALA, L-Carnitine, Creatine and Theanine on a daily basis. Prescription drugs only Pregabalin.

I have no medical or science degree, one must understand that there is a severe risk as Farnesol has not been studied in humans to any degree. Also, I read there is also the assumed risk that it might be bad for healthy immune function. I stopped it for a month now and recently went through COVID. It seems I managed to fight that one off quite well so, anecdotal evidence it did not seem to have had any negative side effects for me so far.

I will put it back on my stack once I am tested negative at 650mg in corn oil and maybe report back in a while.

[Bolt_Upright in reply to Router_]

Thanks for sharing. So... how are you doing? Could you share where you source Farnesol please?

[Router_ in reply to Bolt_Upright]

I live in Germany, you can buy it freely here as an ingredient for cosmetics production. So not technically food grade but as stated above, my risk attitude might be on the unhealthy side of things. Then again, I guess there is technically no "food grade" Farnesol anyhow. I figured if it is of the right quality for topical appliation, can't be much wrong about it.