Mexidol

[Darcy3]

[Mexidol potentiates antiparkinsonian effect of L-DOPA in MPTP-induced parkinsonism model]

Has anyone taken Mexidol and if so did it help you in anyway? I have read mixes reviews. Thank you.

[MarionP]

Would seem to be unknown outside of Russia. Maybe ask Putin?

[LAJ12345]

“Emoxypine, also known as Mexidol or Mexifin when used as the succinate salt, is an antioxidant manufactured in Russia by Pharmasoft Pharmaceuticals. Its chemical structure resembles that of pyridoxine. Wikipedia”Pyridoxine is vitamin b6

[Darcy3 in reply to LAJ12345]

Have you taken it? I ordered some from Russia and hoping to find someone who has experienced good results. My neurologist said it was as you said vitamin B6

[LAJ12345 in reply to Darcy3]

No I hadn’t heard of it. It sounds like it is just b6 with some slight tweaks to the molecular structure so it can be patented. If it works like b6 you would need to be taking it away from medications as b6 can reduce the effect of medications and vice versa.

If it works the same way then to me it would be preferable to use the natural form of b6.

“Pyridoxal Phosphate is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and deamination reactions; it is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction.”

[LAJ12345]

This shows other things that have a similar structure to mexidolpubchem.ncbi.nlm.nih.gov/#q...

Actually it does look quite different to b6 but has some of the same functional groups. Here is b6 structure.

pubchem.ncbi.nlm.nih.gov/co...

[LAJ12345]

Interactions with levodopa carbidopa.wa.kaiserpermanente.org/kba...

“Vitamin B6

Test tube, animal, and preliminary human studies suggest that carbidopa may cause depletion of vitamin B6. However, the use of carbidopa with levodopa reduces the vitamin B6-depleting effects of levodopa. More research is needed to determine whether vitamin B6 supplementation is advisable when taking carbidopa.”

Vitamin B3 (Niacin)

A study in animals has found that carbidopa inhibits an enzyme involved in the synthesis of niacin in the body. In addition, there is evidence that niacin synthesis is decreased in people taking carbidopa and other drugs in its class, raising the concern that people taking these drugs could be at risk of niacin deficiency, even if not frankly deficient. Further studies will be required determine if niacin supplementation is appropriate in people taking carbidopa.

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

[Darcy3 in reply to LAJ12345]

Thank you for the information concerning B6 and B3. It seems best to wait and watch than take at this time.