I started Sinemet IR (25/100) on Jan. 16, 1/2 pill 3x/day. I was supposed to increase to 1 pill 3x/day after a week, but I've only managed a whole pill 3 mornings this week. I'm avoiding protein an hour before and after, so I've tried taking it with a banana, veggies, a couple of crackers, but I get really nauseous, sleepy, and dizzy every time I take a whole pill. I end up lying on the couch for 2 hours yet seeing only minor improvement in my left hand/arm rigidity, mild dystonia, and bradykinesia, and no improvement in left-side tremor.
I've also tried Zandopa and Nutrivita L-Dopa. Zandopa did nothing (tried various doses), and Nutrivita made me severely nauseous (I took it with matcha green tea powder in water).
My question is: If I keep working towards taking the full dose of Sinemet 3x/day, can I expect the nausea and fatigue to resolve over time? If not, I won't keep taking it, as I can't spend hours every day lying on the couch. I should also mention that I'm struggling to keep weight on, so the nausea and limiting what foods I can eat and when I can eat them is challenging.
I'm kind of pinning my long-term hopes on FUS-PTT (I'm 55, diagnosed at 52), but my understanding is that I need to max out the usefulness of meds in order to be considered for the procedure.
FYI, I don't have a follow-up with my MDS until early April (appointments are hard to get). I'm supposed to give him an update soon via MyChart, but I'd like feedback from those who have actual experience with this first.