Can someone please tell me if citicoline is the opposite of a anticholinergenic drug and can/ should they be taken together? Do they offset each other’s effects?
Does sertraline and sinemet have cholinergenic effects and is this why a drug like Kemadrin which is an anticholinergenic drug offset their side effects?
Is this why citicoline is helpful for PD?
Thanks
Strictly speaking the opposite of an anticholinergic would be a cholinergic agonist. Here is a list:
go.drugbank.com/categories/...
But does sinemet and sertraline etc act in a similar way?
Just wondering how Kemadrin works, which is an anticholinergenic drug.
““Kemadrin is used to:
treat and relieve the signs of Parkinson’s disease such as:
stiff muscles, paralysis and tremor
problems talking, writing and walking
producing too much saliva and dribbling
sweating and uncontrolled eye movements
depression.
stop side effects called ‘extrapyramidal effects’, which are caused by some medicines. These may include signs similar to the Parkinson’s disease or restlessness and unusual head and body movements.””
Citicholine is not known to be particularly helpful in PD. You'll do as well everyday by just eating an egg and limiting your sugar intake
I thought that latest video from Laurie mischley said it was helpful but maybe I misremembered where I saw it. I think she said it reduces the amount of levodopa needed to achieve the same result.
Doubt it could make much difference, even if she says it. It's covered by a rate limiting co-factor, and is mostly involved more like the "good" functions of cholesterol. Only a small effect effect in PD and that small effect has to do with increasing dopamine receptor density, not dopamine production, and any effect would be mild and not easy to show, if at all... like I say, its more of an egg yolk thing, more to do with cell membranes and choline. More related to helping reconstitute cells that have been damaged by hypoxia, i.e., ischemic stroke. If there are benefits specific to pd it's not yet been shown. Maybe someday but it's not going to compete for research money and talent that answers better prospects.
Hi Laj, your thoughts occurred to me as well. My husband is the pwp. He was prescribed 10 mgs of nortryptiline a few months ago for pain, excessive saliva etc. It seemed to help with his general sense of well being. But I gave him Double Woods citicoline as he is pretty much maxed out on the meds. Hard to say what's helping, as I am doing so many other things as well. He seems to be a little more himself. But he also has more dyskenisia.
I had the same question- and I did inquire- I take Sinimet & artane, an anticholinergic drug which relieves my tremor better than anything else. I was told that anticholinergics and citicholine (and phosphatydalcholine) do not compete with each other. No worries there...except of course dementia risk from anticholinergics!
Our specialist said it was an old drug too but was prepared to try it at a low dose. He is on 1/4 of a tablet twice a day and I think it is helpful. I think it is offsetting the agitation effects of the madopar and it is making him less stiff in the arms. he is always an overreacter to any drug so he will stick to the low dose
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