Has anyone had bad side effects from taking amlodipine 10mg, Carb/Levo and Azilect?

[Isaiah121]

Has anyone experienced increased tremors or other side effects when taking Amlodipine/ Carb/Levo and Azilect together.

[sharoncrayn]

You can have side effects due to this combination in terms of our BP especially if you are a CVD as well a PD, which I assume you are both. Doubtful it will effect your tremors. Stay off the coffee; stay off the anti-depessants such as SSRIs.

AML is a channel blocker prescribed primarily by GPs to reduce chest pains (angina), lower blood pressure, and reduce blood vessel constriction due to some type of cardio problem.

Azilect (rasagiline) is a newer selegiline and is a MAO-B inhibitor usually prescribed at 0.5-1 mg. per day. Hypothetically, it allows for a reduced dose of generic sinemet (levodopa).

Although rasagiline and sinemet are common combinations for PD, rasagiline alone, and rasagiline plus levodopa prescriptions like sinemet, can increase BP. (I don't believe any CT ha shown a clear risk with rasagiline and orthostatic hypotension. Is this issue a contradiction? Perhaps.)

Therefore, assuming you have a cerebrovascular condition of some sort,

(due to the administration of AML), you should monitor your BP on daily basis (buy a cuff and use it to get a consistent, non-random reading) to maintain what your physician feels is an appropriate level for your age and medical history.

Generally, any BP in excess of 140/90 mmHg (hypertension stage 2 via AHA) is cause for concern. If you go above that level, randomly or consistently, go back to your physician ASAP.

Just be careful with this cocktail. Work with a comptent physician.

Sharon

[Isaiah121 in reply to sharoncrayn]

Thanks Sharon. BP has been good. PD scares me. I want to decrease amount of Carb/Levo 25-100mg. How can I do that safely. I’m taking 1 1/2 tab. Every 4 hrs. although tremors start at 3 hrs. I don’t want to increase because of side effects. I also take Azilect 1mg.

[sharoncrayn in reply to Isaiah121]

So basically 8am,12,4,and finally 8pm with 1.5 tabs per period.

Try going to just 1 tab on one of those time periods. See what happens. If you encounter no change in your tremors, try another period. If your tremors increase, you will have to go back.

Given your cocktail, I would hesitate on suggesting another additional drug. You might try to incorporate some natural COMT inhibitors which I discussed in the recent MP protocol thread (which is quite long by the way). Worth a try to see if any of them work to reduce your levodopa load.

Sharon

[ParlePark in reply to sharoncrayn]

Sharon, can you please post the link to the above mentioned thread?

[sharoncrayn in reply to ParlePark]

let me do it later tonight

[sharoncrayn in reply to sharoncrayn]

healthunlocked.com/parkinso...

The above link should work (I think), or use the search box.for

mucuna-my-natural-protocol?

117 comments.

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"sharoncrayn

sharoncrayn in reply to Stevenmast (original poster)

4 days ago

Other options? You are on the right path. Cut your 98% L-DOPA to as low a dose (per day) as you possibly can without discomfort. It may mean different (unequal) dose at different times, or minimal doses more frequently. It all depends on how it effects you at a given point in your condition.

See how adding a MAO-I like selegiline or COMT (stay away from the drug COMTs) inhibitor might work to even reduce you newer reduced dose.

I was suggesting by simple math that 5.5 grams of 98% L-DOPA is a lot of L-DOPA over an extended period of time which will normally prove to be a serious negative.

I am glad you cut it back.

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Somic67

Somic67 in reply to sharoncrayn

4 days ago

Hi Sharon.

Do you know any natural COMT inihbitor?

Natural MAO inhibitors I know are curcumina (to be taken with butter to maximize absorption) and resveratrolo (wine ).

I read that coffe should be avoided with levoDOPA in fact it gives me muscolar tension.

Thanks a lot for any reply.

sharoncrayn

sharoncrayn in reply to Somic67

3 days ago

You have several natural COMT inhibitors that in sufficient quantity can act like a drug prolonging the effect o L-DOPA.

Green tea polyphenols not only inhibits L-DOPA methylation, but also protects against oxidative hippocampal neurodegeneration.

Also specifically green tea catechins [(+)-catechin.

Specifically, teas high in EGCG and EGC.

Fisetin (which is also MAO-A, best found in strawberries) and Rutin (via green tea but primarily buckwheat)

Bio-active quercetin (related to rutin which is a glycoside of quercetin, but both are low in bioavailability)

To a minor extent, some forms of grapefruit juice (they vary in their ability to act), berries (see Fisetin), cocao as they effect bio-availability.

Pharma wise, you have primarily Entacapone (in Stalevo which is rarely used in US due to prostate cancer issues, but is used as a combination drug)

Sharon

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Sharon

[sharoncrayn in reply to ParlePark]

healthunlocked.com/parkinso...?