Levodopa: Molecular Effects of L-dopa Therapy in Parkinson's Disease.

[aspergerian]

Molecular Effects of L-dopa Therapy in Parkinson's Disease.

2014.

ncbi.nlm.nih.gov/pubmed/246...

[aspergerian]

Protective Effects of Crude Plant Extracts against Aminochrome-induced toxicity in Human Astrocytoma Cells: Implications for Parkinson's Disease.

2019.

ncbi.nlm.nih.gov/pubmed/313...

[MBAnderson]

How many neurologist prescribe nutritional components (B6, B12 and folate) to compensate for the oxidative stress, inflammatory factors, reduced glutathione, etc caused by long-term use?

drugs.com/sfx/levodopa-side...

role of nutrition

ncbi.nlm.nih.gov/pmc/articl...

17 Action Steps to Improve Parkinson’s Disease

drjockers.com/improve-parki...

The Parkinson’s disease death rate: carbidopa and vitamin B6

"During the first 15 years of prescribing L-dopa, a decreasing Parkinson’s disease death rate was observed. Then, in 1976, 1 year after US Food and Drug Administration approved the original L-dopa/carbidopa combination drug, the Parkinson’s disease death rate started increasing. This trend has continued to the present, for 38 years and counting. "

ncbi.nlm.nih.gov/pmc/articl...

[AmyLindy in reply to MBAnderson]

These are great references- thanks- saving to my arsenal. The nutrition article is consistent w/my working knowledge which is comforting & adds layers of validation. Must save for later. How do you organize your PD Arsenal? I was saving as .pdf to a “PD folder” w some various subtitles on Dropbox, ran out of space and started saving to iBook when it pops up and / or iCloud as a document. I’m starting to save everything “compulsively” but need to take a time out to sort /build a system. You seem Uber organized w/links and clear communications- I assume you’ve figured out an excellent filing system already? The new iMac has me curious about iCloud and Desktop- I truly need an admin day to create my best system. Using/reading on iPhone is lazy & leaves you subject to rotating / or random “save” options (it seems).

[MBAnderson in reply to AmyLindy]

I have a fairly articulate filing system. Nothing special, though. I file stuff by subject. The trick is how you label the file.

I've been using Windows 7, but it is no longer going to be supported after January 14, so I have to decide between Windows 10 and a chrome book. I just got a chrome book Saturday, although I'm not certain I'm going to keep it. The extra security and working out of the cloud intrigues me. I am a little concerned about how frustrating it might be to learn the OS system.

[AmyLindy in reply to MBAnderson]

It’s frustrating when stuff is piling up while you’re trying to simultaneously figure it out- for sure!

[aspergerian in reply to AmyLindy]

Try zotero.

zotero.org/

[AmyLindy in reply to aspergerian]

Thx will peek at it!

[MBAnderson in reply to AmyLindy]

PS. I only file links. I don't file the content/pages.

[AmyLindy in reply to MBAnderson]

Great way to save space !

[Rosenmu in reply to MBAnderson]

"L-dopa active ingredient products may be administered as a nutritional supplement or a drug. Nutritional supplements are generally recognized as safe (GRAS), allowing over-the-counter sales.12 Due to side effects, carbidopa is not GRAS.3 It may induce life-threatening events including myocardial infarction, neuroleptic malignant syndrome, agranulocytosis, hemolytic and nonhemolytic anemia, gastrointestinal bleeding, thrombocytopenia, and hypokalemia While carbidopa side effects require its discontinuation when the continuation of L-dopa is indicated, nutrient products are the only option. Most physicians are unaware of the availability of this L-dopa form."

Fortunately, my doctor put me on Mucuna and watches my glutathione levels closely.

[to67 in reply to MBAnderson]

We have a Patented Technology that is made from your mitochondria. It Increases blood flow 55% so it's reducing inflammation and pain. It's proven to increase your own antioxidant production upwards of 500%. Glutathione is your master detoxifier, right? 500% production!!

Is it helping, Yes!

[Farooqji in reply to to67]

Please share the link to your patented technology via PM

[JANVAN in reply to Farooqji]

and iqbaliqbal : >>> received anything ??

[ConnieD in reply to to67]

I would be very interested too, thank you!

[MBAnderson in reply to to67]

Please send me your info via private message.

[JANVAN in reply to MBAnderson]

and Marc >>> received anything ??

[MBAnderson in reply to JANVAN]

I got this message. I didn't call. It is clearly phony.

"Hello there, My name is ...

Since we're 10 yrs old, there's lots that has been proven. I would appreciate the chance to talk first, so I can explain our Patented Technology. I only need 5 min.

Then, I can't wait to send you our Patented Science to review. It will help you and it's not another drug!!

Would you kindly call me and then I can get your email so I can send you our amazing information.

Kindly~

"

[aspergerian]

94 cite Krajcovicova 2011: The default mode network integrity in patients with Parkinson's disease is levodopa equivalent dose-dependent.

scholar.google.com/scholar?...

[aspergerian in reply to aspergerian]

Dysfunction of the Default Mode Network in Parkinson Disease.

A Functional Magnetic Resonance Imaging Study.

ncbi.nlm.nih.gov/pmc/articl...

113 cite Delaveau 2010: Dopaminergic modulation of the default mode network in Parkinson's disease.

scholar.google.com/scholar?...

Dysfunction of the Default Mode Network in Drug-Naïve Parkinson’s Disease with Mild Cognitive Impairments: A Resting-State fMRI Study. 2016.

ncbi.nlm.nih.gov/pmc/articl...

[aspergerian]

Also:

Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.

2015.

ncbi.nlm.nih.gov/pubmed/262...

And:

ncbi.nlm.nih.gov/pubmed/315...

ncbi.nlm.nih.gov/pubmed/308...

Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia.

ncbi.nlm.nih.gov/pubmed/306...

[aspergerian]

Levodopa dyskinesia miscellany.

ncbi.nlm.nih.gov/pubmed?lin...