Low dose aspirin?

[faridaro]

Not sure if anyone had seen this study, but wanted to post it just in case -

"Aspirin: Barking up the right tree?" which presents a study on mice which may not translate to the same results in humans, however conclusion was very intriguing:

"Recently researchers have found that low doses of the pain reliever, aspirin, can increase levels of dopamine in the brains of mice. This finding is interesting because it demonstrates a novel mechanism by which this commonly used drug works. But it is also particularly intriguing for the Parkinson’s community.

It not only highlights a new area of research that could help in the production of novel future therapies, based around this mechanism, but it also raises awareness about a possible confounding factor in the use of L-dopa-based therapies. Perhaps if the results can be independently replicated, a cautionary note should be added to the boxes/bottles of aspirin regarding its use alongside L-dopa?"

Full article scienceofparkinsons.com/201...

[chartist]

faridaro,

I'm wondering if any users of low dose aspirin on this forum have noticed anything in relation to their levodopa intake if it coincides with their aspirin intake?

Art

[faridaro in reply to chartist]

That's was exactly my thought, Art - it would be interesting to find out if aspirin affects action of levodopa in PD patients. Hope someone will share their experience.

[aspergerian]

Parkinson’s Disease and Its Management.

Part 3: Nondopaminergic and Nonpharmacological Treatment Options.

George DeMaagd, PharmD, BCPS and Ashok Philip, PhD.

ncbi.nlm.nih.gov/pmc/articl...

Evidence supporting the role of neuroinflammation in the pathogenesis of PD has led to trials of various anti-inflammatory agents in this setting.79 Wahner and colleagues, for instance, reported that nonsteroidal anti-inflammatory drugs (NSAIDs) may be protective against PD.93 Overall, evidence to support the role of aspirin and nonaspirin NSAIDs in PD is inconsistent, with some trials reporting a possible neuroprotective effect and others reporting little or no benefit.93–97 A prospective study reported that the regular use of 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors (statins) was associated with a modest reduction in the risk of PD.98.

The stimulant methylphenidate, used to treat attention-deficit/hyperactivity disorder and narcolepsy, was reported to improve gait hypokinesia and freezing in PD patients undergoing stimulation of the subthalamic nucleus.99.

Aviles-Olmos and colleagues

[Hidden]

My husband has had PD for 6 years now and is taking Sinemet 25/100. He is currently taking low dose aspirin 81mg and was taking it long before he was ever diagnosed. I personally do not see any difference in him since being diagnosed and on PD meds.

[faridaro]

Thank you for sharing your husband's experience - studies on mice don't always replicate mechanism of drug actions in humans. However, it seems like there are different subtypes of PD and it would be nice to hear from more people.