After consulting by email with Dr. Costantini my wife started B1 at 1000mg per day. We didn’t notice any change in her condition until about 2 weeks later when her tremors (which are the most prominent symptom of her Parkinson’s) became significantly more intense. We have discontinued B1 and will start again next week at 500mg .
Of course, we aren’t certain the B1 is responsible and are wondering if anyone else has had a similar experience.