Guys. Simon of Science of Parkinsons fame, wrote the following about Mucuna Pruriens. I'm pretty disturbed by this as I'm a MP taker and somewhat puzzled as elsewhere he claims that in trials MP has consistently performed much better than CL when it comes to dyskinesia. I thought that this was the appeal of MP (in that we are less likely to get dyskinesia from it). Would be interested to hear from folk who have taken Cl and MP at the same time for a considerable period who have either not developed dyskinesia or those of you who support Simon's statement. And of course any analytical contributions very welcome:
'So, with that said: If I had PD I would definitely NOT be supplementing my normal L-dopa treatment regime with any supplements that contain mucuna pruriens extract (certainly not without discussing it with my clinician first).
This is for one simple reason: high levels of L-dopa (in the lab at least) does bring on abnormal involuntary movements (or dyskinesias) a lot quicker than low levels of L-dopa.
Supplementation of normal L-dopa treatment regimes with mucuna pruriens could significantly increase the level of L-dopa that the body is receiving, raising the risk of developing side effects like dyskinesias. While the short term benefits may be pleasing, the long term picture could be more troublesome as a result of this approach'.