Niacin Increases NAD+ Significantly in Human Tr

[aspergerian]

Niacin Increases NAD+ Significantly in Human Trial | Lifespan.io.

lifespan.io/news/niacin-inc...

[dadcor]

Interesting, almost no side effects with these doses.. How about flushing..?? Just wonder which brand Niacin was used in this trial..??

[Gioc]

Good old B3 NA niacin flush The noble vitamin !

It should never be missing from the vitamin drawer.

Thanks Aspergerian

[billybobAK]

I’ve been taking 300 mg Nicotinimide Riboside (NR) (Tru Niagen brand) for over a year. Stopped for about a month and then reverted to needing a nap to get through the the day so restarted NR. Energy level came back up. Perhaps if I can deal with the flush I may be able to get the results using the cheaper niacin.

[Gioc in reply to billybobAK]

In my experience the flush is managed by going up the dose very very gradually. for example + 50mg per day, every day up to the desired dose, after which keeping the same dose always the flush will rarely and to a lesser extent. It is best to take it on a full stomach to avoid any stomach pain when the daily dose is higher.

I quote scienze of parkinsons here:

scienceofparkinsons.com/201...

And here the legendary Silvestrov talks a lot about it in the middle of the post:

healthunlocked.com/parkinso...

[aspergerian in reply to Gioc]

Thanks for the urls. Helpful.

[aspergerian]

An abundance of B3 findings.

Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications. Mitochondria - 2019.

ncbi.nlm.nih.gov/pmc/articl...

The Influence of Nicotinamide on Health and Disease in the Central Nervous System. 2018 pmc.

ncbi.nlm.nih.gov/pmc/articl...

Niacin: NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus. 2015 pmc.

ncbi.nlm.nih.gov/pmc/articl...

Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule. 2019 pmc riboside.

ncbi.nlm.nih.gov/pmc/articl...

[aspergerian]

BUT SEE:

Nicotinamide vs niacin.

The Histone Deacetylase Inhibitor Nicotinamide Exacerbates Neurodegeneration in the Lactacystin Rat Model of Parkinson's Disease.

Ian F Harrison et al. J Neurochem. 2019 Jan.

scholar.google.com/scholar?...

[Gioc in reply to aspergerian]

healthunlocked.com/parkinso...

[MarionP in reply to aspergerian]

Thus extends life but perhaps not looking so good for PD. Is that the apparent takeaway at this stage? For the moment? I have not read through enough yet.

[Rhyothemis in reply to MarionP]

Boosting NAD+ extends life and is probably good for PD (the main theoretical concern for boosting NAD+ is cancer). This paper reports that high doses of nicotinamide (NAM) could be bad for PD.

NAM is sometimes used as an NAD+ precursor; some say it is not ideal since it can temporarily suppress SIRT1 - again, at high doses. Nicotnic acid (NA), nicotinamide riboside (NR - which as its name suggests can break down during storage to NAM), and nicotinamide mononucleotide (NMN) can all act as NAD precursors and there is some debate as to which one is best. NMN is likely the best but it is also the most expensive.

There are other ways to boost NAD+ besides supplying a precursor, however. You can decrease its breakdown by inhibiting CD38 (increase in CD38 activity is why intracellular NAD+ declines with age in the first place). You could also manipulate salvage pathways, as reported to be effective by Nichola Conlon, CEO of Nuchido - which makes an NAD+ boosting supplement:

youtu.be/75-BxK5ReHM(Not working as expected?)

Non drug/supplement methods to increase NAD+ levels are fasting and exercise.

[Rhyothemis in reply to Rhyothemis]

Dr Brad Stanfield just came out with a video on another potential issue with niacin supplementation - it could affect methylation status and increase homocysteine levels. He suggests also supplementing with TMG (aka betaine):

youtu.be/miS-7t-UUs0(Not working as expected?)

[Rhyothemis in reply to aspergerian]

Currently I take 250 mg NAM / day. I hope that's not too much. I tried NA a few days ago and got an intense flush, 40 mg on an empty stomach. I may try again with a lower dose. I'm worried the prostaglandins will exacerbate my eczema and make my hair fall out. I've taken NR in the past to increase NAD+, but it looks like NA may have an additional benefit:

ncbi.nlm.nih.gov/pmc/articl...

(NAM is not a GPR109A agonist; don't know about NR but I doubt it is ).

[Rhyothemis in reply to Rhyothemis]

I'm wondering if tributyrin would work (work = make butyrate, activate GPR109A)

[aspergerian]

The newest stdy plus a recent review.

...Niacin Cures Systemic NAD + Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy - 2020.

...We administered an increasing dose of NAD+-booster niacin, a vitamin B3 form (to 750-1,000 mg/day; clinicaltrials.govNCT03973203) for patients and their matched controls for 10 or 4 months, respectively.

Blood NAD+ increased in all subjects, up to 8-fold, and muscle NAD+ of patients reached the level of their controls. Some patients showed anemia tendency, while muscle strength and mitochondrial biogenesis increased in all subjects.

In patients, muscle metabolome shifted toward controls and liver fat decreased even 50%...

pubmed.ncbi.nlm.nih.gov/323...

clinicaltrials.gov/show/NCT...

Also:

NAD(+) metabolism: Bioenergetics, signaling and manipulation for therapy. - 2016 - Europe PMC.

europepmc.org/article/med/2...

[chartist]

This article link below suggests that niacinamide/nicotinamide may be the prefered substrate for NAD+ production in the body:

neurohacker.com/benefits-of...

Art

[Despe in reply to chartist]

Art, I would like your wisdom My husband is taking Tru Niagen (NR) 300mg X 2 day. He also takes liquid B-complex with 25mg Niacinamide. In addition, he takes Dr. Birkmayer's NADH 20mg longines before he exercises. Am I poisoning him?? Hahaha

[chartist in reply to Despe]

Despe,

You're not poisoning him, you're the one doing everything that you can to make his quality of life better! Honestly, would he do all the research that you do on his behalf if you were away on an extended visit somewhere else?

Several forum members have mentioned taking Tru Niagen and I think any results from that are going to be slow and subtle because I think I have only recently heard a forum member talk about any benefit from it. With a few exceptions, I think many of the things that are taken to improve quality of life in PWP are of that nature, subtle. As an example, if you take something that actually stops disease progression right where it is, would you know it? Probably not, because you will stay as you currently are which is huge, but no obvious benefit that you will see!!! Any PWP would be thrilled to achieve something so important as stopping disease progression even though there is no immediate change at all to be seen!

Niacinamide at that dose is pretty minimal and well below the amount needed to cause adverse effects and again NADH at 20 mg is not much.

Despe, any PWP would be fortunate indeed to have an advocate like you on their side and feel free to show this reply to your husband! When you've always had someone advocating for you with focus and diligence, as you do for your husband, it can be easy to just assume that this is normal, but at the same time, anyone who has read this forum for any length of time will notice that you are more the exception and not the rule!

Give yourself a hand, Despe!

Art

[Despe in reply to chartist]

Art,

Thank you for your kind words, you make me flash without niacin, hahaha.

He was my rock before PD snicked in in our lives and I have to be his now. He totally trusts me but to be honest with you, he doesn't want/care to research anything. Yes, at times I am so overwhelmed I want to give it up and get away (darn COVID-19).

There are more wives that are just as diligent as I am--I am not the exception!

Again, thank you for your insight. Since TRU NIAGEN is expensive, I will most likely replace it with Niacin.

[chartist in reply to Despe]

If he doesn't like the "flush" caused by niacin, it appears that niacinamide/nicotinamide can do similar without the flush :

neurohacker.com/benefits-of...

Art

[Despe in reply to chartist]

Made the correction,

He never tried Niacin so I have no clue. His liquid B-complex's B3 is Niacin (as Niacinamide).

[Despe in reply to Despe]

Correction: "flUsh."

[chartist in reply to Despe]

I have tried niacin multiple times trying to work my way up to affective dosing, but the "heat flush" always does me in. I no longer experiment with it for that reason. I just wanted you to have an option in case the niacin is too uncomfortable to him.

Art

[Despe in reply to chartist]

Thanks, Art. Trial and error is the name of the game. On the other hand if something is not broken why fix it? Don't know. . . I am so confused at times.

[KERRINGTON in reply to chartist]

Hi Chartist, & Despe... I took Tru Niagen for 7-8 months, in my fatigue fighting efforts. Unfortunately I did not feel any improvement.

[chartist in reply to KERRINGTON]

KERRINGTON,

That was my thought about TRU Niagen is that I had not heard a lot of positive reports about it even though on paper it sounds good. Actually it wasn't until recently that I thought a forum member mentioned increased energy if I remember correctly, but I remember thinking at the time that was the first positive report I had heard.

Perhaps it is slowing disease progression, but that is a very difficult thing to determine in a relatively short period of time. I think Joe/Sunvox has probably taken it as long as anyone on this forum, but I haven't seen him post in quite awhile.

Art

[KERRINGTON in reply to chartist]

Yes, I recall he did/does very well on TN. I also think time of onset may play a part. I've had PD approx 15 yrs, whereas I think Sunvox's

Ataxia ? may be more recent. Sorry Joe if I messed up your info !!

[Gioc]

What could the niacin B3 NA flush do for a Pwp and I quote:

scienceofparkinsons.com/201...

This study from the article above cites a case treated with low dose niacin that notes an improvement in handwriting among other improvements:

ncbi.nlm.nih.gov/pmc/articl...

I also quote this article by Simon where he talks about the other forms of B3 for fairness.

scienceofparkinsons.com/201...