Thiamine HCL and Mannitol concern

[ConnieD]

I knew that Mannitol was a diuretic but was unaware that Thiamine HCl was one as well until I read some recent posts here. I remember many months ago when mannitol was discussed on HU on a regular basis someone mentioning to be cautious on your dosage because being a diuretic the results could be catastrophic if you took too much. Just wondering if this should be cause for concern for those using both. Should you only take one or the other or lower your dose of both. Should this be taken into consideration?

A bit confused thanks for any replies

[park_bear]

Mannitol is used in IV form for various serious medical conditions. For example, to prevent brain swelling as a response to injury the dosage is:

academic.oup.com/bjaed/arti...

"0.25–1.0 g/kg mannitol should be given by i.v. infusion over 20–30 min."

The dosage for Parkinson's is about half the lower value, but taken orally. Mannitol is poorly absorbed so the amount that actually makes it into the bloodstream is less.

I take both mannitol and thiamine and have not personally noticed a diuretic effect.

[ConnieD in reply to park_bear]

Thanks Park Bear!

[Juliegrace in reply to ConnieD]

Me, too. What Park Bear said.

[ConnieD in reply to Juliegrace]

Thanks JulieGrace!

[Smittybear7 in reply to park_bear]

How much of each do you take and do you take them together ? Thanks

[park_bear in reply to Smittybear7]

I am not taking mannitol at this time. The most recent time I was taking I took about a gram three or four times a day, without regard for when I took thiamine.

[Smittybear7 in reply to park_bear]

Why did you quit taking mannitol?Are you going to start it again? The dosage seems high. How much b1 do you take? Thanks for your help.

[park_bear in reply to Smittybear7]

The mannitol dosage I cited is about half of the dosage recommended for me by the clinicrowd website. I stopped because I was is possibly having some adverse effects but it could have been coincidental. I might try again sometime.

The correct thiamine dosage various greatly from one individual to another. Use the dosing instructions at highdosethiamine.org

[ConnieD in reply to park_bear]

Thank you I stopped mannitol for awhile now it seemed after a couple years I was developing gastrointestinal issues. It may not have all been due to mannitol but everything did improve when I stopped taking it. I might try again too.

[Smittybear7 in reply to park_bear]

It is hard to know what dosage b1 I should use since I am using supplements. I started at 1500mg and developed freezing that I didn't have before. I cut back to 1000mg and still having the freezing and constipation. Don't know if I should try to increase back to 1500 or not. Recent blood tests showed folate at 23.i was taken off all b12 which included the bcomplex so basically b1 is the only b vitamin I am taking Don't understand the reason as I am having symptoms of b12 deficiency.

[park_bear in reply to Smittybear7]

If the B-1 seems to be causing freezing I would definitely cut back. Some people seem to do best on much smaller doses then you are taking. Also, B-1 does not remedy everybody's constipation.

What are your B12 levels?

Sally Pacholok on B12, well worth a listen:

youtube.com/watch?v=5MKLdo-...(Not working as expected?)

[Smittybear7 in reply to park_bear]

Thanks for sharing the information on b12.i definitely will get tested. My question to my nutritionist is why did you take me off b12 for 6 weeks when I had a reading of 23. For folate. I definitely have signs of b12. Deficiency..my pcp did not include b12 on my last bloodwork. I appreciate your information. Thanks again The video was very interesting and helpful.

[park_bear in reply to Smittybear7]

Excessive folate is definitely not a good thing. Not complicated – If your level is too high the remedy is to stop supplementing the folate. I presented important information here:

Folate Supplementation Carcinogenic

tinyurl.com/ycdrz5lj

[Smittybear7 in reply to park_bear]

Why would I have been told to cut b12 ? How do you cut folate and how often should I have my blood checked?folate is in a lot of supplements and foods. Is 23 an extremely high number for folate or is it just a little above the acceptable range.?

[park_bear in reply to Smittybear7]

Dietary folate is not a problem but supplementation is. I wrote about what I did to reduce my folate supplementation at the link.

There are different units of measurement for folate levels - μg/L or nmol/L.. To understand the meaning of your number the measurement unit is needed.

[Smittybear7 in reply to park_bear]

Thanks! hope you are doing well what is the link?

[Smittybear7 in reply to Smittybear7]

I found the link. So you shouldn't take any folate.????

[park_bear in reply to Smittybear7]

Correct, unless testing shows it is warranted.

[Kia17]

No side effects so far. Taking both.

[ConnieD in reply to Kia17]

Thanks Kia I feel reassured!!😊

[lempa_nik]

Why is the diuretic effect "catastrophic"? If not too extreme, it just means that a person needs to pee more often. I think the laxative effect, including possible loose stools and diarrhea, would be more awkward. But an average-size adult who takes less than 20g/day, should avoid the latter problem.

[ConnieD in reply to lempa_nik]

I don’t remember who posted it but the word stuck in my mind it was about how if you take too much mannitol what it does to the intestines . I remember being concerned I was taking the proper dose because of it. It definitely made me worried about taking too much. Thanks for your response dumpekin!

[Hidden]

I’ve been taking bath and have not had any side effects.

[134A]

I am also taking both with no problem

[chartist]

Connie,

Things that act as a diuretic can tend to deplete magnesium, potassium and zinc, but how strong of a diuretic action is important in making that determination. From member reports so far, this combination does not seem to have a strong diuretic action, but nothing wrong with asking your doctor to test your magnesium, potassium and zinc levels at visits or just before visits to be safe.

Art

[ConnieD in reply to chartist]

Thank you Art!!😊

[kaypeeoh]

I'm aware that gastric enzymes can affect absorption of most medications. So I've ordered sublingual drops which are absorbed bypassing the stomach. I just noticed B1 is available as as an animal drug. I don't mind experimenting so if the drops are a bust I'll order the B1 injectable.

[House2]

Diuretics can lower blood pressure. This can make light headedness worse.

[LAJ12345]

My husband takes the tbs of mannitol and 1000mg b1 or 1500mg alternating days. He finds if he takes the 1500 every day he needs to pee more. 1000 and he doesn’t but symptoms start to worsen if on just 1000. His sweet spot is in between I think. If you take too much your body flushes it out by making you pee more. Makes sense!

[LeharLover62]

So I’m not sure about this, still experimenting, but I think mannitol is starting to exacerbate my husbands orthostatic hypotension, and when we added high dose thiamine back into the mix it got better. I’m really curious to see what others are experiencing.

[Fumaniron]

1 take 1 heaping tablespoon mannitol a day, and 2 grams thiamine HCL twice a day. Been doing for a couple of years now. working well for me