One of the best articles I have seen on sinemet and its side effects. It covers it all and explains it. Also requip and mirapex

[parkie13]

mentalhealthdaily.com/2016/...

At the end of the article there's a link for the same kind of information on requip and mirapex

[grower]

It's tricky isn't it when a lot of those side effect symptoms are general PD ones.

[MBAnderson]

Excellent article. Very comprehensive. It reminds me that one can never read too much about Sinemet. I was diagnosed in July, 2011 and am one of those who feel one should delay Sinemet as long as possible. I began taking one at bedtime about two weeks ago and may rethink that, but it minimum, this article reaffirms my decision to take as little as possible for as long as possible. Sinemet affects every aspect of brain functioning in complex ways.

A couple of statements stand out.

“This is because the brain may downregulate dopaminergic processes as a result of regular Sinemet administration, leading to abnormally low dopamine signaling.”

“Levodopa-induced dyskinesia (LID) is estimated to occur in 9% to 80% of levodopa users. Once levodopa-induced dyskinesia is fully established, it is highly-difficult to treat.”

[MBAnderson in reply to MBAnderson]

It seems to me, this statement is critically important in the decision to take or not take sentiment

“This is because the brain may downregulate dopaminergic processes as a result of regular Sinemet administration, leading to abnormally low dopamine signaling.”

When I was first diagnosed, the neurologist immediately prescribed Sinemet, even though my only symptom was a minor tremor my left hand, hardly something you would take an exotic drug for. I decided not to start the drug because at the time I was reading two schools of thought, one of which postulated that Sinemet accelerates progression. I haven’t seen much back and forth about that over the past couple years, but if this statement is true and our body’s production of dopamine is diminished as a direct result of taking Sinemet, the result of that would be an accelerated progression.

I’ve discussed this with my neurologist at the VA and he acknowledges the jury is not in on this question. Hence, I remain ambivalent.

[aloha24 in reply to MBAnderson]

So then what are you taking to relieve symptoms?

Thanks,

Aloha24

[parkie13 in reply to aloha24]

I just suffer

[MBAnderson in reply to aloha24]

I started taking Rasagiline about two weeks ago. that's all. other than that, I follow the usual prescription for diet, exercise, and supplements.

I'm torn about it, though. My symptoms are fast becoming problematic, especially when I'm out in public.I began trying out Sinemet about two weeks ago. I took one pill at bedtime and help my sleep a lot, but only for three days, then nothing.about 1/2 a dozen times I've taken a pill during the day but can't say I really can tell a difference.

So I'm kind of at a loss for what to do.

[aloha24 in reply to MBAnderson]

Thanks. I appreciate the information!

[parkie13 in reply to aloha24]

I have been following Marty hinz protocol. I have been taking twice or three times a day eighth of a teaspoon of hundred percent levodopa I know that I am under medicating it's not doing that much good. Also I just saw my neurologist and I have started on CR carbo levodopa so far I am taking half a pill twice a day. Again I have not seen much of a difference however I do see a difference when I don't take it I don't know what to do. I misunderstood your question when I said I just suffer.

[Enidah]

I was sorry to see that the article didn't mention non-movement symptoms of PD. It is recognized generally that this is much more than a movement disorder. I also found many of the side effects they list for sinemet are simply the symptoms of PD. And many, such as anxiety and constipation, show up way before a person is even diagnosed or given meds.