New prognostic markers and better understandi... - CLL Support

CLL Support

22,367 members38,474 posts

New prognostic markers and better understanding of risk groups?

HAIRBEAR_UK profile image
HAIRBEAR_UKFounder Admin
1 Reply

A recent study has brought together prognostic data to include the recently discovered molecular markers: BIRC3, SF3B1, and NOTCH 1. The hope is that in time a better prognostic algorithm will become available that may include testing for these genetic lesions to guide therapeutic decisions. A changing diagnostic landscape to match the changing treatment landscape?

Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia

The abstract concludes: “These findings may have relevant implications for the design of clinical trials aimed at assessing the use of mutational profiling to inform therapeutic decision”

bloodjournal.hematologylibr...

Many will not be able to access the full article, DR Sharman has written his summary and overview on his blog in patient friendly language: That explains a great deal about the advancing knowledge. Ending with the question

" How do these markers hold up in the face of the new drugs. ABT-199, ibrutinib, CAL-101, GA-101 .Will traditional markers hold up in the "new era?"

There are many questions.

New CLL Risk Groups

cll-nhl.com/2012/12/new-cll...

Other topics discussed by Dr Sharman in December::

How did I get lymphoma / How did I get CLL? cll-nhl.com/2012/12/how-did...

When to treat CLL cll-nhl.com/2012/12/when-to...

Recent NEWS from the UK government: DNA tests to revolutionise cancer treatment

and help 100.000 NHS patients number10.gov.uk/news/dn...

"We will soon be able to sequence a human genome for less than £1,000, and the cost is likely fall further. As a result, experts believe a revolution in the way healthcare is delivered is approaching, with personalised medicines and individualised treatments becoming available for the first time.

The sequencing of 100,000 patients’ genomes in centres capable of sequencing DNA at speed in the UK will further drive down the cost, delivering value for money in comparison to the current NHS tests for cancer and rare diseases that provide a more limited snapshot of information."

Written by
HAIRBEAR_UK profile image
HAIRBEAR_UK
Founder Admin
To view profiles and participate in discussions please or .
Read more about...
1 Reply
jangreen profile image
jangreen

Hi these are all the new research developments which offer such hope. Lets hope they are succesful.

You may also like...

Prognostic markers and the future. Genetic testing.

February 24 2013. Prognosis Markers Defined.. http://www.cll-nhl.com/ DM W & W 13q

Dr Sharman's survey to assess the CLL community's understanding of new treatments is now closed

his site for new articles inspired by the survey responses here: http://www.cll-nhl.com Neil...

Understanding prognosticators early on

I've watched all the videos on Patient Power and Cll Society. I've read what I can. And now sifting...

Dr Jeff Sharman on Nutritional Supplements

topic that a lot of patients want to know more about\\"....

I am in high risk group?

should of received the government letter. I have had cll for nearly 15 yrs. Get infections all the...