More from ASH about some of the novel therapie... - CLL Support

CLL Support

23,088 members39,649 posts

More from ASH about some of the novel therapies in trial

HAIRBEAR_UK profile image
HAIRBEAR_UKFounder Admin
2 Replies

The latest News broadcast from Andrew Schorr at the ASH conference may have just hit your

in box? You can view it here:

patientpower.info/video/big...

.

Dr. John Pagel, from the Seattle Cancer Care Alliance, discusses the advances that

signal a potentially changing treatment landscape in CLL Pagel explains some of the new drug

therapies, including insights from ASH 2012, that may mean a move away from chemotherapy

for some patients.

Ibrutinib, GS 1101 and ABT-199 are changing the CLL treatment landscape, plus antibody

therapies such as GA 101 and novel therapies such as TRUO16 and the exciting T cell mediated therapies in research CART etc. All of these are moving away from toxicity treatments for the future.

Interesting times, The New Clinical Trials will be discussed with us at Cardiff in January by Professor Chris Fegan a clinical trials expert.

cllsupport.healthunlocked.c...

UK Trials portfolio ncrndev.org.uk/downloads/Tr...

Nick

Written by
HAIRBEAR_UK profile image
HAIRBEAR_UK
Founder Admin
To view profiles and participate in discussions please or .
Read more about...
2 Replies
Mikey47 profile image
Mikey47

High Nick,

Yes, it dropped in my mailbox at 6.30 this morning.

Such exciting and encouraging news!! Especially with the other developments. T cell therapy was featured on TV this week, used on a little girl who is now free from Leukaemia (but only after problems with 'the overactive' t cells). Am I right that this isn't in trials yet?

I spoke to consultant about maybe going on a trial for Ibrutinib, or Ibrutinib+R when the time comes for treatment. I certainly feel far more optomistic now about the longer term future.

Best wishes

Mikey

Cllcanada profile image
CllcanadaTop Poster CURE Hero

T cell therapies are highly experimental. They may one day replace stem cell transplant, but due to the costs involved they will never be standard of care... even with a huge economy of scale. And there certainly are road blocks to be overcome still, but some are slowly falling.

Should be found as a cure or even life long control over the next few years, then perhaps this will change, no crystal balls.

CAR T19 is in two pilot clinical trials, and MDAnderson plans a new trial for a CAR target called ROR1. The big advantage for this target is it is selective to malignant B cellls and much less selective to good B cells, the CLL 'holy grail'. CART 19 kills all B cells like rituximab, GA101 etc... wiping the B cell immune response.

However, I think the future is very bright, still distant...and cost will dictate all... especially in the UK and Canada for example...

Not what you're looking for?

You may also like...

OncLive 9 CLL Videos - Optimizing the Treatment of CLL With Novel Therapies and more Take-home messages from ASH 2021

The OncLive Chronic Lymphocytic Leukemia condition center page is a comprehensive resource for...

ASH 2019 CLL highlights and 'hot' topics - Drs Nicole Lamanna & Florence Cymbalista

Prof Nicole Lamanna - ASH 2019 - Maturing CLL clinical trial data Dr. Nicole Lamanna, Associate...

ASH 2013: Dr. John Pagel Speculates on the Future of CLL Therapies including the late breaking data on Idelalisib

ASH 2013: Dr. John Pagel Speculates on the Future of CLL (chronic lymphocytic leukemia) Therapies...

Reflections from Cardiff, news of CLL research and the changing trials landscape

Hi everyone After reflecting on yesterday's Cardiff CLLSA patient meeting and...

ASH 2018: Professor Peter Hillmen on the Combination of Ibrutinib and Obinutuzumab in CLL: Timing Matters

Today we start with an important abstract from the United Kingdom that may have significant...