NAD infusion therapy

[Sheepherder]

Is it save to have a NAD (nicotinamide-adenine dinucleotide) infusion while taking acalabrutinib? My PA recommended I check with the pharmacist who was uncertain if it was ok. My fatigue is getting worse. Has anyone else found this to be helpful? Thanks!

[Spark_Plug]

What is a "NAD (nicotinamide-adenine dinucleotide) infusion" ?

[AussieNeil Partner Administrator in reply to Spark_Plug]

New to me too!

From this 2020 overview Clinical Evidence for Targeting NAD Therapeutically

ncbi.nlm.nih.gov/pmc/articl...

Note the Conclusions

Based on the human trials conducted to date, NAD pharmacology is a promising treatment strategy that is likely to be safe for human use. However, despite several decades of active investigation, there is still only suggestive evidence, in the form of a few successful and sufficiently powered clinical trials, for NAD upregulation to be effective for any of the many potential indications where it may benefit patients.

Further trials are justified: about half of the published trials identified in our review reported patient benefits. Most of the indications tested require further studies for replication because only a single trial has taken place.

In general, it is the case that more and larger studies are required to produce robust data in support of NAD pharmacology. This includes in particular studies in which different forms of NAD upregulation are compared consistently with one another. For example, exercise programs tailored to older individuals may be more effective than all of the existing approaches to NAD pharmacology. Whether or not this is the case is one of the more important questions for the research community to answer.

There's not much about NAD in previous posts:-

healthunlocked.com/cllsuppo...

Neil

[Spark_Plug in reply to AussieNeil]

Thank you, Neil. It seems that the move toward infusion treatments has picked up in popularity. I don't ever remember any of this growing up, hospitals were the only places one observed I.V.'s of any sorts.

[SeymourB]

Sheepherder -

Vitamin and nutrient Infusion "therapies" outside of standard medical care are a fashionable thing hyped by celebrities that are catching on in alternative and functional medicine due to demand. They're largely unregulated in most states. The standard risks of purity and dosage standardization apply. Despite sciencey looking claims on websites that may cite scientific papers, the actual product delivered may differ from what the paper tested. As usual, in-vitro papers are unreliable evidence for effectiveness.

I think that infusion centers for these products differ greatly in staffing and safety protocols, too. An infusion at an actual medical center is likely physically safer than one at a storefront or non-medical office building. I would want to know if the staff have medical licenses - MD, certified Nurse Practictioner, or RN. Do they follow standard safety protocols for infusions - alcohol pad wipe of the infusion site, new, packaged needle and tubing, BP and temperature check.

I'd also want to know what exactly is being infused, who manufactured it, and what dosage. The clinicians may use generic terms, but there are apparently differences between NR, NRH, NMN, NAD, NADH, NAD+, etc. The doses and effects for each might not be comparable.

I'd want to know what additives are used. Since these are not FDA approved therapeutics, there's no standard FDA package insert. But some companies do follow standard pharmaceutical practices for documentation.

I would feel more comfortable if the infusion was prescribed by a department of a major cancer center than by someone not specialized in cancer. I would want some assurance that the infusion therapy does not increase the CLL or interfere with the acalabrutinib action. Use of the therapy to prevent cancer is a very different thing from using it while having a specific cancer. I'm not a microbiologist, but it seems to me that increasing NAD in the body to boost general metabolism would also boost cancer metabolism. I would want CBC/differential and a metabolic panel done a day or so after several of the infusions to indirectly monitor effects on the CLL and other body processes.

Best of luck,

=seymour=

[GoneWalky]

A few years ago I was quite interested in NAD and it's metabolic relatives based on David Sinclair's propaganda about NMN, then some info from Rhonda Patrik. I was looking for any info in the research having to do with lymphocytes... decided against, since there was some chance of increasing lymphocyte count. I am sorry I do not have the citation for this. If things have changed, and there is more certainty regarding effect on B-cells, I'd like to know!