Introducing the Phase I EUPLAGIA-1 study (EudraCT 2021-003815-25), which investigated GLPG5201, a CD19 CAR T-cell therapy, in relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) and Richter’s transformation (RT). Patients enrolled in the study received a freshly manufactured product, with a median vein-to-vein time of 7 days. This CAR-T therapy showed encouraging efficacy with a tolerable safety profile.
vjhemonc.com/video/cc8pjzj8... - includes a 4 minute video. The speaker, Valentin Ortiz-Maldonado, MD, predicted a phase 2 study would "maybe" start next year.
For further details of the study, see ash.confex.com/ash/2023/web...