Ibrutinib stopped working, what’s next - CLL Support

CLL Support

23,324 members40,026 posts

Ibrutinib stopped working, what’s next

Stacky66 profile image
9 Replies

Morning all,a quick recap on journey so far, FCR treatment which kept things at bay for 14 months, then onto Ibrutinib for 6 years approximately, currently lymph nodes at 5cm , next treatment starts in January Rituximab and Ventoclax for 2 years, just wondering if there are any alternatives? Thanks all Merry Christmas and Happy New Year

Written by
Stacky66 profile image
Stacky66
To view profiles and participate in discussions please or .
Read more about...
9 Replies
lankisterguy profile image
lankisterguyVolunteer

Hi Stacky66,

-

I've been where you are, and about to change from my 5th targeted therapy to my 6th.

IMO(no medical training)- the most popular and proven effective is obinutuzumab / Gazyva(ro) and venetoclax / Venclexta, but some health systems are still using rituximab / Rituxan with venetoclax. Either of those combinations seem far ahead of everything else that would be available.

-

Since you seem to be resistant to the covalent BTKi family, only the PiK3 family like idelalisib/ Zydelig , non covalent BTK like pirtobrutinib / Japirka, and CAR-T are approved so far, but the results are less impressive than venetoclax. See: cllsociety.org/cll-medicine...

-

Len

Stacky66 profile image
Stacky66 in reply tolankisterguy

Thank you

Skyshark profile image
Skyshark

There is a trial of triple combo Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR). I think this is the best way to use non covalent Pirtobrutinib after progression on covalent BTKi. Pirtobrutinib is not approved yet. Evens chance of getting PVR and the other arm VR is what's on offer anyway.

Churchill Hospital, Oxford

Royal Marsden Hospital, Surrey

bepartofresearch.nihr.ac.uk...

Stacky66 profile image
Stacky66 in reply toSkyshark

Thank you

Jm954 profile image
Jm954Administrator in reply toSkyshark

Good trial 👍

GeriGi profile image
GeriGi

I think obinatizamab with venetoclax is preferred treatment.

Stacky66 profile image
Stacky66 in reply toGeriGi

Thank you

MovingForward4423 profile image
MovingForward4423

There are trials for reversible BTK that overcome resistance seen in Ibrutinib and other non reversible BTK. May be worth doing some research on trials that may be available.

Skyshark profile image
Skyshark

UK NICE has only approved VenO for NHS first line. VenR is approved for2nd/nth line.

Not what you're looking for?

You may also like...

Ibrutinib stopped - What treatment next ?

I am a 78 year old male living in the UK. Started treatment 3 years ago. Had two rounds of FCR...
Haileybury profile image

acalabrutinib stopped working. Can switching to venclexta help?

I am on acalabrutinib for two years. In first year my wbc went down from 150k to 18k, and for the...
Belkin123 profile image

Ibrutinib

I know many are following the issue regarding NHS England's behind closed doors decision not fund...
Mick491 profile image

Possibly Failing Calquence - what’s next?

Turning to this very informative group for answers while waiting for my follow up visit after...
ReneeSusan profile image

IBRUTINIB - for 21 months, now stopped

It's been a year or so since I last posted about my Ibrutinib progress. Here is my latest...
Haileybury profile image

Moderation team

See all
Newdawn profile image
NewdawnAdministrator
CLLerinOz profile image
CLLerinOzAdministrator
AussieNeil profile image
AussieNeilAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.