Replacement for Evusheld

[TroutFly]

Does anyone know if a pharmaceutical company is working on a replacement for Evusheld and, if so, has it started trials? Several months before emergency approval for Evusheld was withdrawn I read that an updated version was in the works but I have not heard or read anything since.

[KMac1969]

Yes, it is called SUPERNOVA trial.. Astra Zeneca is currently doing this..

astrazeneca-us.com/media/st...

[Pacificview]

Very encouraging Supernova trial ....

[bkoffman CLL CURE Hero]

Beside the AZ's SUPERNOVA trial, others are working on PrEP including Invyvid. We have a link to their pre- trial on our website, CLLSociety.org. Others are also working on it, but those are the most advanced.

[Lrodk]

AstraZeneca is developing an updated version of Evusheld that they hope to bring to market later this year, pending regulatory approvals and hurdles. Phase 3 clinical trials will be underway here in the US in the coming weeks.

[skipro]

hi

I’ve heard FDA required a prospective randomized trial

1/2 of folks get placebo

I’ve been told it is a year out from possible FDA approval

Makes no sense to deprive immune compromised a drug that could be life saving

And

Who knows I if it will work against the variants at the time it’s approved

Skipro