Evusheld and Booster

[desti]

What is the current protocol for booster shots after having received the final prescribed dose of evusheld. I had taken it in 2 divided doses.

[SofiaDeo]

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[cllady01 Former Volunteer]

According to this posting by American Academy of Allergy Asthma and Immunology titled:Evusheld and COVID-19, dated 2/22

"The FDA recommends waiting 2 weeks after any COVID-19 vaccination before starting Evusheld. Currently, it is recommended COVID-19 vaccination should be delayed 90 days from the administration of monoclonal antibodies or convalescent plasma for treatment of acute illness."

aaaai.org/Allergist-Resourc...

[Jph02006 in reply to cllady01]

Thank you for posting this link. The quotation you included in your post that recommends a 90 day delay specifically addresses treatment with monoclonal antibodies "for acute disease". I dont think it is correct to interpret this recommendation as the FDA specifically addressing Evusheld. The author of the article goes on to address Evusheld specifically and to my inexpert reading seems to be more ambivalent. He is clear that it is preferable to get vaccinated and boosted BEFORE getting Evusheld and suggests postponing later boosters until a month before the next treatment with Evusheld. But he also seems a bit skeptical that the vaccine will significantly reduce the effect of Evusheld. For example, he states "I will add that I am skeptical that the presence of monoclonal antibody or passive antibody will significantly modify the vaccine response. This is based upon the robust vaccine response in individuals with prior COVID-19 (3)" He does not ,however, opine on whether getting a booster after Evusheld will reduce the efficacy of Evusheld.Bottom line seems to be there is no definitive answer to the sequencing of boosters after Evusheld. I think those interested in this issue should read the full article and discuss with their own doctor.

Thank you for finding this article.

John

[cllady01 Former Volunteer in reply to Jph02006]

Agreed: read and talk with your own Dr. before acting on what you have read.

More reading: fda.gov/media/154701/download

[desti in reply to cllady01]

Thanks for your response as well as John's. It seems to be to early for any clarity on this issue. More wait and see being the answer at this point in time.

[Cgolen99 in reply to Jph02006]

Completely agree. I did just that and discussed this all with my oncologist several times. She felt strongly that further boosters would interfere with Evusheld and I should just concentrate on getting the Evusheld every 6 months. Having contracted COVID for the first time 6/3/22, receiving my last vaccine last September, and Evusheld in January and February this year, and also having a fairly mild reaction to COVID, I am confident in her assessment for me! 🥰