Thus far 3 Pfizer’s zero antibodies. Do I get 4th Pfizer now, or hope for Evusheld within the next two weeks? If I get Pfizer now, per protocol, cannot have Evusheld for two weeks, in the unlikely event that it is offered to me
Evusheld vs 4th Pfizer ?: Thus far 3 Pfizer’s... - CLL Support
Evusheld vs 4th Pfizer ?
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Davidcara
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I would consider the Moderna full strength for my 4th shot and hope you aren’t offered the Evusheld for the next two weeks.
Panz 💕🙂💕☘️
David,
The chance of you making antibodies in sufficient numbers while on Ibrutinib are not very good.
Why not let them inject you with antibodies in sufficient numbers that will let you fight this virus immediately and for 6 months or more?
No vaccines work well for us and this one is no different. It’s not a matter of if but when you will be exposed to this variant.
Get the Evusheld.
Jeff
I hear you, but it could be weeks or months before I get Evusheld. I’ll probably think about this for a while.
David,
Show me any article that shows a fourth shot given to someone on a BTK inhibitor with CLL developing a robust response with a high level antibodies.
But if you can locate the Evusheld somehow, you’ll have that instantly.
Just my position and I support yours either way. This whole situation sucks!
Jeff
I agree, I would say the chance of ME making antibodies from a fourth Pfizer, is only greater than not taking a fourth Pfizer. I have tried to get Evusheld but, here in California you can not even get someone to say, yes we have it. I’m going to hold out a little longer, hoping for the great Evusheld light to shine down on me.
🥃I’ll drink to that and most anything else these days.
Evusheld is in VERY short supply and I have seen nothing about the US govt purchasing more.
I do know that at Stanford University Medical Center (here in California), Evusheld is being given (at the present time)to transplant patients only.
I’ve been told that even Sotrovimab will only be given to those testing for “zero” antibodies post vaccination.
Perhaps things will change in a couple of weeks. I hope they will.
Yes Jeff —- this whole situation sucks!
We tend to make less antibodies than solid organ transplant patients. That’s if you exclude lung and small bowel transplants. I get what they are doing, they are trying to save their patients, and at the same time save the transplanted organ. Lots invested in transplant patients.
Yes, but a life is a life. We should purchase enough Evusheld as to protect anyone who may not do well with Covid. That would include over 60's, etc.
Even the fact that Sotrovimab is given to patients with "zero" Ab response to vaccines is making a big set of assumptions about the results of an inexpensive spike protein IGG test.
The money for this stuff is available - it's being spent like candy. What I think is the issue is that ...
1.) People are fixated on the results of 2,3, or 4 vaccinations to a virus that has mutated a long time ago and may not be that relevant.
2.) People don't want these biologic treatments being given away to the "vaccine hesitant" instead of just vaccinating them.
I agree, it would be great if we could all get protection.
We could ... that is ... if the powers that be took our situation seriously.
No one can come up with a definitive set of criteria that CLL people need to live by - so I feel that we need to be given these treatments as safeguards until it is proven that we do not need them.
I don't want to risk Covid just because the feeling is that to give away therapeutics runs the risk of being abused.
Here in Florida doses of Evusheld are only trickling in but I may have been able to get an appointment for this Saturday for my husband. Will be about an hour's drive but worth it. I had a better chance of getting it last week before some news articles came out today about it and where it is available but was waiting for oncologist's approval and he never called. I called again today and got the message that he said he was not opposed to him having it. We are on a waiting list will know in 24 hours. I think the doses may be getting more out this week since more people are asking about it. Florida had several thousand doses but had not released them supposedly saving for the most needy people and secretly sent to only a few places one being a private business while county public hospitals could not get them. Well now if you have cancer you are included in that need. So we'll wait to see. I would not try another vaccine and hope that Evusheld will become available and also there is the Paxlovid if you get it and Sotrovimab.
healthdata.gov/Health/COVID...
I sorted the above document by state. There are 600 available shots at Tampa General Hospital, a research hospital. I suggest looking up the Evusheld Fact Sheet first. It mentions heart events have occurred and not taking if blood platelets are low.
I was injected on the PROVENT trial with a platelet count around 75. There's no special problem with Evusheld and low platelets. From the FDA fact sheet (my emphasis):
As with any other intramuscular injection, EVUSHELD should be given with caution to individuals with thrombocytopenia or any coagulation disorder.
I had this exact conversation with my doctor yesterday. He told me that the Evusheld he has currently is only enough for transplant patients. I got my third Pfizer in August. He wants me to get the Moderna now since I didn't make many antibodies either. Like you, I was hoping for the Ebusheld and searched for it on the data base I found here. Very little is coming into my state or the state where I go to the hospital. (MO and KS). I found a Moderna for Jan 21, so that is what I am doing, hoping that eventually I will get the other. Such a crap shoot, but if I don't get the Moderna, I don't get anything, so......I will try that next.
Check with your state department of health. Doctors can be ill informed. Like ours just because their hospital doesn’t have it doesn’t mean it is not available in other locations
I saw that my hospital received Evusheld so I sent an informed email asking to be considered. This was the response; "Although we do have access to Evusheld, it is not available yet. We currently have a task force working on an equitable distribution strategy for the limited supply available. That is all we know at this time. Please check back with us.". So yesterday after getting this reply I saw that Pfizer has an omicron specific vaccine in March so now I wonder if I should get the 4th shot or wait for this new one!!
I think doses are finally getting out. Keep checking.
In Florida just having cancer meets criteria
I asked my hematologist on their portal if they would prescribe it for me. They replied that they are reserving it for patients in treatment. I’m not in treatment yet.
Yes I understand the reasoning, I just wish such a great treatment is so limited. Ironically at my October hematologist visit I was told I should start treatment very soon, and thought I’d be starting by now. But last week had another visit and my labs were slightly improved so the doctor said let’s wait and see in 3 more months. I am happy not to be starting during this COVID wave, and I am glad, but I had been psyching myself up to start treatment!
I hear and feel for you. I was supposed to start treatment March 2020. My oncologist decided to postpone my treatment until May 2020. He felt even though the treatment was ibrutinib, my immune system would take a hit at the beginning of the treatment. When it was obvious covid was not going anywhere, we decided May 2020 to start the treatment.
Please don’t take my previous statement about those being on treatment should be first for Evusheld. That was just a generalized statement.
There are many things to look at. Those in treatment could mean folks like me, or those on chemo who are totally wiped out. So many factors.
Many facilities will have strict protocols, some will make the distribution more personalized. Others could unfairly distribute Willy Nilly. Who knows?
On a personal level, maybe you could talk to your MD, about your immune status. Did you make antibodies to the vaccines, how are your immunoglobulins, do you have other risk factors?
Let’s hope, that this treatment will soon be available to all that need it. Until then, take care Justaguy.
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