Paxlovid and Calquence

[Brucex100]

Im a 62 yo male - Ive been on Calquence for 3 months - going well

I just got COVID and my Gp prescribed

Paxlovid

I did some research and there is an issue with

Paxlovid increasing the levels of calquence - So I plan to stop calquence while i take the anti viral for the next 5 days

I have read that calquence only stays in system for 12 hours -

Any thoughts here??

[Panz]

That is exactly what I would be doing and I have run it by my doctor should I get Covid. You take care!!!

Panz 🙏💕🙂☘️

[gardening-girl]

This is what the CALQUENCE prescribing information says:

For strong CYP3A inhibitors

Avoid concomitant use.

If these inhibitors will be used short-term (such as anti-infectives for up to seven days), interrupt CALQUENCE

(Paxlovid is a strong CYP3A inhibitor)

den8dhaj6zs0e.cloudfront.ne...

So, it looks like you plan to do exactly what is recommended. The only other precaution is if you have moderately reduced renal or severely reduced hepatic function.

Dose reduction for moderate renal impairment (eGFR ≥30 to <60 mL/min): 150 mg nirmatrelvir (one 150 mg tablet) with 100 mg ritonavir (one 100 mg tablet), with both tablets taken together twice daily for 5 days. (2.2)

 PAXLOVID is not recommended in patients with severe renal impairment (eGFR <30 mL/min). (2.2, 8.6)

 PAXLOVID is not recommend in patients with severe hepatic impairment (Child-Pugh Class C)

fda.gov/media/155050/download

Sorry about the Covid diagnosis. Here's hoping you have an easy time of it.

gardening-girl

[Brucex100]

UPDATE - I stopped Calquence and then did a reduced dose of Pax - that was last night - no issues - this morning did the full dose of pax and feel like it is helpingfrom the research you cant take calquence and pax together

[Analeese]

I was also told not to take my statin while taking Paxlovid.