Ibrotinib and high level of TSH

[Green202]

Hello,

I'm wondering if anyone taking Ibrutinib has experience with treatment for high levels of TSH regarding thyroid. Thankful for feedback.

[LeoPa]

Do you have autoimmune disease causing hypothyroidism? Like Hashimoto's thyroiditis? What did your endocrinologist say? If the reason is an autoimmune condition I would start to investigate how to fix or improve the underlying cause. A lot of times it is triggered by what we eat. There are foods not everybody's thyroid gland is able to tolerate well.

[danimal7777]

Hi Green, I have Hashimoto's, so my thyroid numbers are always somewhat out of whack, and have been for many years. However, after taking ibrutinib, then acalabrutinib for a year and a half, my free T3 continues to escalate to the point that I've needed to reduce the amount of liothyronine I take daily.

I have no idea if the BTK drugs have potentiated a higher level of T3 and T4, or whether my thyroid has started becoming more functional. TSH has dropped to a very low value.

[Jungle-Jim]

Biotin may be the cause - it can reap havoc with your TSH. Most OTC bottles even post a warning to that effect. You find it in many multiple vitamins, but a lot of folks take it as a stand-alone supplement. Best to check with your doctor! Jim

[janvog]

I take Imbruvica since 3 years. My TSH has been normal. I take levothyroxine for hypothyroidism. Possibly your levothyroine dosage or brand needs changing

[Green202 in reply to janvog]

Thank you very much for your helpful comments

[janvog in reply to Green202]

Across the years have been multiple problems with the potency of levothyroxine both generic manufatured as well as brands. This always needs attention both by the regulatory authorities as well as doctors. A change of manufacturer or brand should often by contemplated.