Neutropenia/low ANC and Ibrutinib/BTK Inhibitors

[Davidcara]

Wondering if anyone knows what the usual treatment is for neutropenia related to ibrutinib. I know there is neuplasta. But I thought I saw somewhere that some just hold the ibrutinib for a period of time, and restart it without further issues. Thanks for your input.

[AussieNeil Administrator]

See this previous discussion: healthunlocked.com/cllsuppo...

Neil

[Davidcara in reply to AussieNeil]

Thanks Neil, appreciate it.

[Jm954 Administrator]

I wouldn't be keen to stop it unless there was no alternative, especially in the early months. Have a discussion with your doctor, see what they think.

Jackie

[Davidcara in reply to Jm954]

Oh yes, definitely would not do anything without doctor’s advice

[very]

Nic, you are certainly not a moaner, it's good to share how you are feeling. I went to my first WI meeting since March 2020 and was very nervous, but it was well organized.jenny uk

[Dawson21]

This happened to me on Venetoclax - ANC dropped to 0.4 - I was prescribed Accofil (Filgristam) as a self-administered injection (3 times weekly) which immediately raised the level to 13.7 then dropped to around 5 where it has stayed.

[rubberlegs68]

My oncologist reduced my dosage each time my neutrophils became low from 420mg of ibrutinib to 280mg and then to 140mg. I've remained on the this dosage and my neutrophils have been stable since then.