Possible role of melatonin in CLL

[nuji]

Would our admins have any views on this? I value their feedback more than any paper.

Requires Authentication Pre-published online by De Gruyter August 5, 2021

Potential role of melatonin in prevention and treatment of leukaemia

Ming Guan Ng, Khuen Yen Ng, Rhun Yian Koh and Soi Moi Chye

From the journal Hormone Molecular Biology and Clinical Investigation

doi.org/10.1515/hmbci-2021-...

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Review ArticleMing Guan Ng, Khuen Yen Ng, Rhun Yian Koh and Soi Moi Chye*Potential role of melatonin in prevention andtreatment of leukaemiadoi.org/10.1515/hmbci-2021-... January 31, 2021; accepted July 6, 2021;published online August 5, 2021Abstract:Leukaemia is a haematological malignancyoriginated from the bone marrow. Studies have shownthat shift work could disrupt the melatonin secreti

[AussieNeil Administrator]

Looks like it hasn't been peer reviewed, plus as it's paywalled, I can't check if the paper reports any actual testing against CLL. It's challenging to develop CLL cell lines for laboratory investigation, because CLL cells aren't immortal, they just propagate faster than they undergo apoptosis. healthunlocked.com/cllsuppo... So most leukaemia research articles like this report testing on other leukaemia cell lines, usually the myeloid cell line.

Here's an example:bpspubs.onlinelibrary.wiley...

It reports intriguing differences in the melatonin serum levels in long term shift workers (like this abstract) pubmed.ncbi.nlm.nih.gov/274... but the reported research is for the HL-60 and other acute leukaemias.

Neil

[LeoPa]

Interesting. We all secret melatonin. Need to avoid the disruptors of melatonin secretion.

[BooksellerGuy]

Interesting. Worked shift work for several years while in the Army and later for a year as a civilian. Looking forward to seeing the research.