Things change fast.
1.More data coming that suggests T cells probably will not be rescuing us post vaccine if not antibody (humeral response). No surprise there. CLL patients usually have lousy T cells—sorry.
2.Discouraging data from a small trial where no-one with CLL who did NOT respond to the first 2 shots responded to the 3rd dose: assets.researchsquare.com/f...
3.No safety issues seen with the booster so that’s good, but the risk of an auto-immune reaction should be consider in folks like me who have had such complications including ITP or AIHA
4.The LLS vaccine data was surprisingly better in CLL and BTKi patients than in other studies. Most untreated or 1 year post treatment patients were seropositive.
CLL Society’s Recommendations for COVID-19 Vaccinated Chronic Lymphocytic Leukemia (CLL) Patients-Based Upon the CDC’s Updated Considerations for People Who Are Immunocompromised and Other Underlying Data ( cllsociety.org/2021/07/cll-... ) is still good guidance.
Big new CLL Society COVID guidelines and checklists coming soon.
Just finished our ASH abstract on MRD and fixed duration, very competitive but hopefully its will be accepted.
We are all in this together.
Brian Koffman MDCM (retired) MS Ed
Co-Founder, Executive VP and Chief Medical Officer
CLL Society, Inc