Seed and soil: CLL cells and the mesenchymal stromal cells that keep them alive

[bkoffman]

Hi,

CLL is easy to kill in the blood, but in the marrow and the lymph nodes, it has a huge network of support cells that helps keep it alive. Dr. Kay out of Mayo may have a way to outsmart it. Please take a look at my interview with him from ASH 2018 cllsociety.org/2019/08/ash-...

Stay strong.

We are all in this together.

Brian

Brian Koffman MDCM DCFP, DABFM, MS Ed

Co-Founder, Executive VP and Chief Medical Officer

CLL Society, Inc.

cllsociety.org

[DriedSeaweed]

I wonder if this would be really helpful for people with high cd49d expression?

Looks like Duke, Washington University and Cornell are participating with Mayo: clinicaltrials.gov/ct2/show...

[bkoffman CLL CURE Hero in reply to DriedSeaweed]

CD49d is associated with T cell stimulation and a poor prognosis. I am forgetting any link with Vit D.

[DriedSeaweed in reply to bkoffman]

I wonder if cd49d T cell stimulation can help explain autoimmune issues.

[Smakwater]

Great Work!

JM

[Doremefasol]

Thank you Dr. Kofffman.