Obinutumab plus venetoclax in cll

[Rameshchag]

My father got diagnosed cll october 2009,was on wait and watch till mid 2014,then given R-bendamustine and was on remission till october 2016,then started ibrutinib in 2016 and stopped ibrutinib in mid 2018,in 2020 end due to fast multiplication of tlc and enlarged spleen and lymphnodes our doc suggested o+v and started day 1 with 100mg of obinutuzumab and day to at 900mg,day 8 with 1000mg of obinutuzumab and day 15 again with 1000mg obinutuzumab,and introduced veneto ramp up 20mg dose for one week on day 31 along with 1000mg obinutuzumab,platelets are 10 and hb hover around 7gm,tlc is 2,he needs infusion of platelets and PRbC every other day,bone marrow aspiration shows diffused infiltration of lymphocytes,

Just want to know how long it will take platelets and haemoglobin to bounce back if anybody has gone through similar situation.

Thanks

[AussieNeil Administrator]

We are all different, both in our CLL markers and our past treatment history, so expect a wide range of responses. You'll likely get more replies too, if you edit your post to make it private to this community, rather than discoverable by anyone on the internet. This post explains the pros and cons of locked vs unlocked posting:

healthunlocked.com/cllsuppo...

Your father's past treatments may also have an influence, depending on how well his bone marrow recovered after the last treatment. How well did his haemoglobin and platelets recover from his Ibrutinib treatment time wise and how high did they climb?

Neil

[GB10]

I did the V+O and my hemoglobins and platelets got to good levels after 3 months. Went into remission one year later in April 2021. I relapsed last April only after two years in remission. Now have to find a new treatment and still investigating what is the most effective for a quick relapsed.

[AussieNeil Administrator in reply to GB10]

Hi GB and welcome to our community. I expect you found us through an online search which reported this unlocked post.

You haven't shared much of your experience with your CLL journey in your bio, which you can update via this link healthunlocked.com/profile/... but if you've only had V+O along with perhaps older chemoimmunotherapies (BR, FCR), then your specialist is likely to recommend maintenance therapy with acalabrutinib or zanubrutinib. You'll find lots of shared experiences on these BTK inhibitor (BTKi) drugs, in particular the breakthrough first generation BTKi, ibrutinib in this community.

Are you aware that because you reside in the USA, you can register for a free video consultation with a recognised CLL specialist through the CLL Society's Expert Access Program? cllsociety.wpengine.com/pro... It's a brilliant service, particularly for those who have difficulty accessing a CLL specialist near where they live.

Neil