prophylactic Drugs and ibrutinib

[Elnaazz]

Hi friends, the doctor has prescribed Trimethoprim ,Allopurinol, and Valasiklovir ,Flukonazol, drugs for my father along with ibrutinib . Does anyone have any experience with this? And did your doctor prescribe these drugs in addition to your medications?

[Sepsur]

I am on a different prophylactic antibiotic, antiviral and gut settler. I was on allopurinol to prepare me for Venetoclax, it lowers Uric acid levels because the kidneys takes a bit of a battering.

I didn’t feel great off allopurinol- I know this because I started taking it ahead of everything. I also struggled with a few different antivirals - being acutely allergic to some.

After a few of months of up & down - I now tolerate them all fairly well.

[Elnaazz in reply to Sepsur]

Thank you for sharing your experience

[Smith123456]

fluconazole is a powerful cyp3a4 drug which is counter indicated with ibrutinib. you should have your doctor look into it and be prepared to adjust the dose. I had a similiar issue with a drug i was taking for my trigeminal neuralgia(carbamazapine) which was also a powerful cyp3a4 drug. I had to change to another drug for my trigeminal neuaralgia so i could take the ibrutinib. all this is listed in the drugs package insert.

[Elnaazz in reply to Smith123456]

Thank you for sharing your experience

[SofiaDeo]

When I was taking the infection prevention drugs (trimethoprim, valacyclovir, and fluconazole) along with ibrutinib, I was getting some side effects that appeared to be from the drug-liver enzyme interaction that Smith123456 mentioned. I got lips that were dry & cracked, so then the amount of fluconazole was decreased. Also, all these drugs can sensitize skin to the sun. I got a very severe rash when my arms were exposed even briefly. It made my skin look & feel like leather, and took about a year to clear up. These problems, along with GI issues from the ibrutinib, had me stopping the ibrutinib.

[Elnaazz in reply to SofiaDeo]

Thank you for sharing your experience

[ThreePeas]

I am not taking anything other than ibrutinib (just diagnosed, in my early 60s),

[Elnaazz in reply to ThreePeas]

Thank you for sharing your experience