Venclexta 400mg and leg cramps

[msccsm11]

Coincidence or side effect?

[GMa27]

Many of the oral meds have that side effect. Magnesium Glycinate 400 twice a day helps. My leg cramps were only in bed. Place a small bar of soap (Ivory if u have) under fitted sheet by calf area. It actually works! 💕

[MsLockYourPosts Passed Volunteer in reply to GMa27]

I have seen doctors write about this with comments to the effect that there is no way that they can explain it, but that it seems to work for some patients.

[cllady01 Former Volunteer]

Please consult your treatment provider or GP/PC for possibilities of causes of your muscle cramping.

the following link to a Mayo article can give you talking points for questions as to the cause of any cramping specific to you.

mayoclinic.org/diseases-con...

[LeoPa]

Lack of minerals is known to cause leg cramps too among other things. Magnesium, potassium. sodium and others. They are important for the nervous system to function properly.

[morepork]

Bars of soap have never done a thing for my Ibrutinib triggered muscle cramps.

[GMa27 in reply to morepork]

Bummer....I wish it did for you. I don't know if it has to be Ivory but I was told to use that. 🙏

[Smakwater]

msccsm11,

Although I cannot positively identify the connection to leg cramps and my treatment with either obinutuzumab or venetoclax, I can state that I developed leg cramps shortly after beginning treatment. I discontinued treatment 10 months ago on December 12, 2019.

At first the cramps happened at night in bed. Now they occur both at night and during the day. They occur at random and have increased in frequency and intensity. I have discussed the phenomenon with my oncologist, GP, and rheumatologist of which none can offer a indication or resolve. There is no apparent deficiency revealed through their tests and observations. My diet is balanced, I have no influencing habits such as alcohol, tobacco, recreational drugs etc... I take only two prescribed drugs - allopurinol and omeprozole, and have only supplemented regularly with vitamin C. Although the doctors are aware that omeprezole can influence cramps, I have been using it for years previously and they have stated that it is not the cause.

Not without dedicated study I have experimented with diet changes, supplements including magnesium and potassium, remedy specific exercise and stretching, I even quit taking the prescriptions for time.

In a nut shell -

I have leg cramps post treatment that I did not have before.

I have given much though and effort to relieving the cramps.

So far, nothing has worked, I have no absolute measures, and they continue to worsen.

I am still looking for answers.

I apologize for the offering of facts without resolve.

Hopefully something will arise from your post,

JM

[AnneHill in reply to Smakwater]

My sodium is low. I find using salt on some foods has helped. I also have stomach issues and occasionally use rehydration salts. I try to drink plenty too.

Obviously salt isnt suitable for everyone. I buy lo salt and have never put salt on the table. My results showed my sodium was too low. I do season now but not too much. Cramp a lot better. Anne uķ

[country76 in reply to Smakwater]

I had leg cramps with ibrutinib. First it was thighs then is was arms, abdominal, arms, hands, back and neck. I took mag/phos salts that helped a little. Warm compresses help. Eventually they effected just walking or using my hands. I switched to Alacabrutinib and they stopped.

One time I took mag/phos tablet and ate some saltines. It worked that day.

[Smakwater in reply to country76]

Interesting that the switch to Acalabrutinib may have made a difference.

[country76 in reply to Smakwater]

It was like waking up from a bad dream. I put all my potions away. I was amazed. There are just a few minor things that carried over.

[Smakwater in reply to country76]

That's Great!

[Smakwater]

I hope the sodium keeps working for you Anni.

Thanks for sharing

[Ellieoak]

I think what you are missing is that water is Very Important when on Venteclax. If you are getting enough water then it may be a mineral causing the problem. Magnesium, potassium, or calcium. Stay safe, Anna

[Octavia17]

Vitamin B complex tablets works very well for my husband leg cramps which were nightly and severe . Available over the counter in the UK . Good luck.