Does anyone have any data or medical journal articles, addressing the contagious for either Pre symptomatic infections or individuals that have asymptomatic viral infections..
Also, in my home state of Utah in the USA, I have not been able to find any published data on the current incident or presence of Covid or other viruses in the community. Does anyone have any good data or source of data to help guide me in determining how much diseases in the community!
I am on months 15 of V+ O Relapsed 2 years after 3 months FCR stopped due to profound neutropenia for nine months.
As I’ve mentioned many times in this forum, my wife has not been supportive of protecting me from infection but had started becoming more willing to wear masks in a very few select
She recently told me that she would never ever wear a mask again anywhere.
She said that she’ll tell me if she gets sick.
So any data on the percentage of individuals who have asymptomatic viral infections, or how long a symptomatic individual could be contagious would be most useful as I try to reevaluate my risk around my spouse.
Thank you so much
Snowshoe
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skipro
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You are in a tricky situation. Unfortunately, the O will have a long term impact on your infection risk. She might not understand how much this drug may make you vulnerable.
I am on twice daily Atovaquone to as prophylaxis to pneumonia. My CLL Specialist wants me to stay on it even post treatment just in case. So, if you catch something maybe you can have some protection with this.
Keep an eye out for antibody opportunities. I haven’t closely tracked their development since I currently have enough. I’m sure people have posted about it here.
Fortunately, you live in Utah so hopefully a lot of the things you might want to do out-and-about are outdoors. You could consider turning down going places that you think are high risk.
I bought a Coway air filter during early covid since we didn’t know how easily it spread. I continue to use it in the hope it could snag anything floating around the house.
I suppose just do what you can to protect yourself with masking and hand washing.
I wonder if you could prompt the doctor to discuss how vulnerable you are with O treatment when she is present? Also, how long it will stay in your body post treatment.
Here in the San Francisco bay area they have announced on the news that there is a new uptick. They are still testing water for the data. (Health dept?). Sorry that your wife is not on 'your side' of this ever-going fight against COVID. My husband and I both mask anytime we are in an indoor setting. For the immune-compromised COVID will never be over. Stay strong and positive, Chris
State Dept of Public Health has whatever data they collect on ALL communicable diseases. Looks like the state is formally only tracking hospital admissions on Covid; IDK if a particular county is looking at nonhospitalized patient reports.
While as fate would have it, I was ill and tested positive for Influenza A 11 days ago and took antiviral med for 10 days. I'm pretty sure I know where I got it.
I think that data on asymptomatic viral infections will never be available anywhere. Because asymptomatic people are never tested for viral inspections. They look and act healthy.
Regarding the incidence of Covid in the community, there is only one reliable source of data: hospital admissions, and that records only the tip of the iceberg, i.e. the most severe cases. The vast majority of cases will go unrecorded as symptoms are minor. I doubt there is any systematic monitoring of antivirals dispensed to immunocompromised Covid outpatients.
We are starting to see a summer wavelet of Covid in the United States, as reflected by a small bump in wastewater levels and emergency department visits, influenced by the FLiRT variants KP.2 and KP.3, more immune-evasive than the prior dominant JN.1 variant. The graphs below from Jay Weiland show where we stood recently, with hope that this uptick will not culminate into a significant jump in cases. The main point is that Covid is not going away, and while the current status of circulating virus is pretty favorable, we’re only one “Omicron-like” event away from seeing a more threatening challenge to the immunity that has been built to prior versions of the virus. The toll of the FLiRT variants for sharp rise of infections In Singapore, New Zealand and Australia should be kept in mind, since we can’t foretell what will happen here in the weeks ahead (or track it well)
The hospital admissions graph for Region 9, which includes Arizona and California, shows the recent uptick in Covid, substantiated by a minor US-wide uptick based on waste water samples.
Regarding pre-symptomatic transmission of SARS-Cov2 (and other airborne respiratory viruses) An individual is infectious if carrying and shedding viable infectious SARS-CoV-2, regardless of whether they have symptoms [31]. The infectivity period is the period during which people can transmit SARS-CoV-2 to others. An infected person can transmit the virus up to two days before they experience symptoms, indicating that the pre-symptomatic phase of COVID-19 is highly infectious. ecdc.europa.eu/en/infectiou...
A number of studies and meta studies have come up with figures of pre-symptomatic transmission comprising upwards of 40 % of all Covid cases in the community.
Of course, as an immune-compromised individual you are more than usually vulnerable to airborne transmission of SARS-CoV2 and other viruses from someone sharing the same air space who may be pre-symptomatic. N95 masks in public would seem to offer a sensible risk reduction measure.
What is your trough IgG level? If you only get an infusion when less than 400, it might help to have your trigger level raised to 500 or 600 mg/dL or think about going from IVIG to more frequent subcutaneous infusions.
Of course, it doesn't attempt to assign case counts to population.
I recommend doing semi-quantitative COVID spike IgG testing before you get your next booster, and again 6 weeks later to compare the numbers. While there's no accepted standard from what's completely protective, values in the thousands are what normal people score. Numbers below 100 are not likely to prevent much disease. This test only looks at specific antibodies stimulated by an mRNA vaccine which are also stimulated by an infection, and doesn't directly measure T-cell protection or innate immune response. But innate immune cells and helper T-cells are necessary to produce the result.
It's fairly cheap - $79. The test is available for ordering yourself from Quest Diagnostics, test code 34499:
The result is an index value, not an antibody count. Anything above 1 is considered positive, but like I said, not necessarily protective to any specific degree. A value of 2 is certainly not protective, for example. Whatever value that results is based on antibodies from past exposures and boosters. Hence the need to compare values over time. The peak response to the vaccine has been demonstrated to happen between 4 and 8 weeks.
TBH, COVID is not nearly as deadly as it once was. Early Paxlovid, and better hospital care make a huge difference. But figure in your comorbidities to estimate your risk. The people who die are seriously compromised in kidney, liver, and other functions in addition to immune-compromised. My kidneys, liver, and heart are good. I had a 2 digit score on that test a month ago left over from an infection in 2022. I had a year of treatment on pirtobrutinib, obinutuzumab, and venetoclax. I have no CD19 B-cells on flow cytometry, and my IgG, IgA, and IgM are 355, 37, and <12.0 mg/dL. I mask indoors outside the home. My wife does not mask all the time any more indoors outside the home, but may start again in August when she goes back to teaching. She does distance.
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At what point in CLL am I supposed to have reduced immune function?
My GP just said something about CLL and Covid
