resveratrol

[Research123]

This is interesting. Been taking resveratrol for the last year as saw it as a general health thing but might be good on a small scale for combatting leukemia if I've read this right

ncbi.nlm.nih.gov/pmc/articl...

[AussieNeil Administrator]

Resveratrol was identified as an interesting natural substance for research in a paper listing such contenders for the management of CLL about 10 years ago. So it's interesting to read an update. Did you catch this, in section 5 - RSV and Challenges in Humans?

"RSV doses of 5 μM increased the proliferation of CD19+ B lymphocytes in a statistically significant manner while a concentration of 10 μM inhibited B lymphocyte proliferation. These data suggest that RSV affects human B lymphocyte proliferation and apoptosis in vivo." So in my opinion, not something to experiment with unless you are sure that you can guarantee a constantly high enough concentration to always ensure inhibition!

The paper goes on to mention a poorly done in vitro study, so it's back to watching this space.

Neil

[Research123 in reply to AussieNeil]

Thanks Neil, I hadn't picked up on that. I guess that means either take bucketloads or not at all.....

[AussieNeil Administrator in reply to Research123]

With respect to maintaining a high serum level, in the Conclusions and Perspectives section you hit the next barriers:-

"The low bioavailability of the parental compound based on poor resorption and extensive biotransformation is a well known limit of the molecule. "

and later, "However, the already mentioned rapid conversion to different metabolites hampers the definition of a suitable, recommended dose for a given disease."

So you probably have the challenges of having to take a high dose regularly throughout the day and night to maintain a continuously high enough enough serum level to avoid CLL proliferation and higher serum levels usually result in unwanted side effects. There's not much on what these may potentially be in the article - we need more in vivo human studies.

This is where pharmaceutical companies add value, by working out what molecular modifications can be made to increase both bioavailability and to slow the conversion rate, so sufficiently high serum levels are maintained without having to have ano IV drip, in the worst case. Then you have to hope that the efficacy against CLL is maintained or even improved without an increase in side effects/adverse events.

Neil

[Research123 in reply to AussieNeil]

I really appreciate your input on this forum Neil - frankly I have trouble understanding a lot of this. Maybe I'll cut it out for now then.

[Motoli in reply to AussieNeil]

I eat black grapes almost daily. A glass of good red wine is also useful. No resveratrol needed and my HDL is quite high.

[BluMts in reply to AussieNeil]

Many thanks to you Neil and everyone else who has posted here. I've been taking a daily capsul of 200mg of Trans-Resveratrol in capsules that also contain an absorption booster called ResWinol. Now concerned and have to read the links you and JM954 give here.

[Jm954 Administrator]

Interesting molecule and it sounds promising in a lot of areas but there's a long way to go before this could be unequivocally recommended as much of this work has been in animal models.

People taking Ibrutinib should be careful if they're temped to take it as "high resveratrol intakes in the form of supplements could enhance both bruising and bleeding risk when taken with anticoagulant drugs, antiplatelet drugs and even non-steroidal anti-inflammatory drugs (NSAIDs). Resveratrol has been reported to hinder human platelet aggregation in vitro."

Another interesting paper here: ncbi.nlm.nih.gov/pmc/articl... it says RSV has much potential but also highlights some of the potential issues.

Interesting subject, thanks

Jackie