Stem Cell Transplant

[steve_canada]

My doctor says that after a 2nd remission, meaning after ibrutinib and venetoclax have failed that a stem cell transplant is the next option.

I have been on IB for 14 months and it has been amazing but I am terrified about doing a stem cell transplant.

Can someone share their experiences if you have had a SCT?

[lankisterguy Volunteer]

Hi Steve,

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There is a list, on this page, of many discussions about Stem Cell Transplants. See: " Related Posts

*Blood Stem Cell Transplant

*Ibrutinib and then stem cell transplant

*2Stem Cell Transplant Questions

*Stem Cell Transplant Blog from Dr. Dave

*outpatient stem cell transplant"

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And as you visit those pages, look for the same box (upper right column on computer screens or scroll way below on mobile devices) since the list will change according to the words in the title.

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Len

[steve_canada in reply to lankisterguy]

Thanks Len I will check it out

[Hidden]

as time goes on new stuff keeps coming. you might be able to avoid one. also there are more than one kind of stem cell transplant. If your not seeing a cll specialist at a major institution-see one. i have a local oncologist and a dana farber specialist.

Dana farber like most of the big institutions is 'tied in' to all the latest stuff and learn stuff in their trials that doesn't come down to local levels for months.

maybe you can get one of these

blog.dana-farber.org/insigh...?

[cajunjeff]

Just seeing this Steve. I think as time goes along new options for Cll treatments short of a transplant will continue to develop. Two such options are already here and showing promise in clinical trials are Car-nk and Car-T therapies.

Ibrutinib could work a long time for you. I think Car-T will increasingly become an option going forward as they learn better how to do it through ongoing clinical trials.

[steve_canada]

Hi Jeff, I know about CarT but never heard of Car-nk. I’ve been progressing well on IB and hoping to do anything but a stem cell transplant.

[AussieNeil Administrator in reply to steve_canada]

CAR-T is the more established procedure, using T-lymphocytes, hence the 'T'. In fact, the original trial included some CLL patients. With the experience gained since then, researchers have found that CAR-T works better on other cancers than it does on CLL. Recent CAR-Natural Killer lymphocyte trials look to be a better fit than T-lymphocytes for CLL, hence CAR-NK. Both are still considered experimental, so I agree with Cajunjeff that other options are probably a better choice, leaving CAR-T or CAR-NK for later, when the technology has improved, success rates have improved and the cost has come way down.

Meanwhile there are second generation versions of Ibrutinib (non-covalent) that could well work when Ibrutinib fails and there's a second generation BCL-2 inhibitor that may work when Venetoclax fails. healthunlocked.com/cllsuppo... After those, who knows what else will be available that is less risky than a CAR-T or CAR-NK treatment - assuming that by then CAR therapies haven't dramatically improved.

Neil

[Grundick54]

Stem cell rejuvenation is becoming more and more common and as youth is not a thing to return to, I decided to learn as much as possible about this procedure. I came across an interesting article on the Internet, stemcela.com/stem-cells-mul..., which describes everything in detail. Now I have plans to find a good cosmetologist who will take care of me.

[KAS8]

Hi. I realise this is an older post but not been on here for a while and I was wondering what route you took.