Cll

[sweetromeet]

Hi,my dad was detected with CLL I December end,wbc720000,HBO 5.5 .He has undergone 2 chemos of rituximab and endoxon,ie,cyclophosphamide.

From today he started ibrutinib 420 ,he is having severe backache ,headache and also little feverish.are these side effects? He is 80 yrs old.Now his count is 290000

[81ue]

He must have started a lower dose of ibrutinib and worked up to 420, correct? He should be in contact with the doctor with these symptoms because kidney pain vs back pain is something the doctor needs to sort out (if kidney, then it may be related to the medication and something serious). Also fever above 100.4 always needs to be brought to doctor's attention to avoid the danger of untreated sepsis. Call the doctor now.

[Mldeterm in reply to 81ue]

Ibrutinib is normally started at full dose, it’s a slow acting drug vs Venetoclax that you have to ramp up carefully to avoid tumor lysis.