The BCL-2 family regulate one of the body’s apoptotic pathways. As scientists understand more about these proteins, they are able to push the boundaries of cancer research.
The BCL-2 family is broadly divided into two types: pro-survival proteins, including BCL-2, BCL-XL, BCL-W and MCL-1, which help keep the cell alive; and pro-apoptotic proteins, which promote cell death. These two types of BCL-2 proteins typically work together to regulate apoptosis.
More about how AbbVie engineered a new drug to target both BCL-2 and BCL-XL which might be helpful for us CLLers here:
nature.com/articles/d42473-...
Note this is an AbbVie advert for their research in the journal Nature
Jackie