trial to know if venetoclex and ibrutinib together can overcome ibrutinib resistance

A trial is going to start to see if adding venetoclex to ibrutinib resistant patients can create a synergisic affect thats beneficial to both drugs.

I've seen anecdoctal comments from patients on the web but no actual trial proof until now. I am no expert on trials but i don't think companies and NIH do trials(spend money) unless they think there is a reasonable chance the trial will be positive.

clinicaltrials.gov/ct2/show...

[lankisterguy Volunteer]

I will be looking for a trial to see if either Calquence/Acalabrutinib or one of the Non Bindind BTK inhibitors can provide a synergistic effect to Venetoclax.

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I became resistant to Idelalisib/Zydelig and could not tolerate Ibrutinib/Imbruvica, now after 36 months of Venetoclax, I am no longer U-MRD, so need a plan F- as the first 4 (b,c,d,e) did not last,

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Len

[Justasheet1 in reply to lankisterguy]

Len,

What BTK’s are you looking at besides Acalabrutinib? Did they identify the resistant clone?

Jeff

[lankisterguy Volunteer in reply to Justasheet1]

I don't know of a specific target.

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Like Hidden I have read some anecdotal comments that Ibrutinib restores or reinvigorates exhausted T cells in synergy with Venetoclax, but I cannot bear the rash I get from Ibrutinib.

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Since my skin biopsies already show too many T cells in my skin, it will be interesting to see if the other BTK actors will give benefits without the side effects.

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So any trial I can qualify for, in the NYC area will be my target.

BCR Inhibitors

Acalabrutinib (Calquence)BTKCLL/SLL

Ibrutinib (Imbruvica)BTKCLL/SLL, DLBCL, MCL MZL,

Buparlisib (BKM120)PI3KDLBCL, B-NHL

Copanlisib (Aliqopa)PI3K γDLBCL, MCL

Idelalisib (Zydelig)PI3K δCLL/SLL, DLBCL, FL

Cerdulatinib (PRT062070)SYK JAK 1-2FL

Entospletinib (GS-9973)SYKCLL/SLL

Fostamatinib (Tavalisse)SYKDLBCL

TAK659SYK/FLT3DLBCL

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Len

[Justasheet1 in reply to lankisterguy]

Len,

Being intolerant of ibrutinib obviously is different than being resistant, as you know, so any should work.

I hope that you can find one that’s easy on your skin.

Jeff